Title:	Altered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractography
Authors:	Bispo, Diógenes Diego de Carvalho Brandão, Pedro Renato de Paula Pereira, Danilo Assis Maluf, Fernando Bisinoto Dias, Bruna Arrais Paranhos, Hugo Rafael Glehn, Felipe von Oliveira, Augusto César Penalva de Soares, Alexandre Anderson de Sousa Munhoz Descoteaux, Maxime Regattieri, Neysa Aparecida Tinoco
metadata.dc.contributor.affiliation:	University of Brasilia, Brasilia University Hospital, Diagnostic Imaging Unit University of Brasilia, Faculty of Medicine University of Brasilia, Neuroscience and Behavior Lab Hospital Sírio-Libanês, Brasília Brazilian Institute of Neuropsychology and Cognitive Sciences, Advanced Psychometry Laboratory Hospital Santa Marta, Department of Radiology, Taguatinga Hospital Santa Marta, Department of Radiology, Taguatinga Hospital Santa Marta, Department of Radiology, Taguatinga University of Brasilia, Faculty of Medicine Hospital Sírio-Libanês, Brasília Instituto de Infectologia Emílio Ribas, Department of Neurology University of Brasilia, Faculty of Medicine University of Sherbrooke, Sherbrooke Connectivity Imaging Lab, Sherbrooke, QC, Canada University of Brasilia, Faculty of Medicine
Assunto::	Disfunção olfativa Covid-19
Issue Date:	2023
Publisher:	Springer Nature
Citation:	BISPO, Diógenes Diego de Carvalho et al. Altered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractography. Scientific Reports, [S. l.], v. 13, art. n.12886, 2023. DOI: https://doi.org/10.1038/s41598-023-40115-7. Disponível em: 20 set. 2024.
Abstract:	We aimed to investigate changes in olfactory bulb volume and brain network in the white matter (WM) in patients with persistent olfactory disfunction (OD) following COVID‑19. A cross‑sectional study evaluated 38 participants with OD after mild COVID‑19 and 24 controls, including Sniffin’ Sticks identification test (SS‑16), MoCA, and brain magnetic resonance imaging. Network‑Based Statistics (NBS) and graph theoretical analysis were used to explore the WM. The COVID‑19 group had reduced olfactory bulb volume compared to controls. In NBS, COVID‑19 patients showed increased structural connectivity in a subnetwork comprising parietal brain regions. Regarding global network topological properties, patients exhibited lower global and local efficiency and higher assortativity than controls. Concerning local network topological properties, patients had reduced local efficiency (left lateral orbital gyrus and pallidum), increased clustering (left lateral orbital gyrus), increased nodal strength (right anterior orbital gyrus), and reduced nodal strength (left amygdala). SS‑16 test score was negatively correlated with clustering of whole‑brain WM in the COVID‑19 group. Thus, patients with OD after COVID‑19 had relevant WM network dysfunction with increased connectivity in the parietal sensory cortex. Reduced integration and increased segregation are observed within olfactory‑related brain areas might be due to compensatory plasticity mechanisms devoted to recovering olfactory function.
metadata.dc.description.unidade:	Faculdade de Medicina (FM) Hospital Universitário de Brasília (HUB)
Licença::	(CC BY) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/ by/4.0/.
DOI:	https://doi.org/10.1038/s41598-023-40115-7
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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