Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/50397
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_AlteredStructuralConnectivity.pdf1,92 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorBispo, Diógenes Diego de Carvalho-
dc.contributor.authorBrandão, Pedro Renato de Paula-
dc.contributor.authorPereira, Danilo Assis-
dc.contributor.authorMaluf, Fernando Bisinoto-
dc.contributor.authorDias, Bruna Arrais-
dc.contributor.authorParanhos, Hugo Rafael-
dc.contributor.authorGlehn, Felipe von-
dc.contributor.authorOliveira, Augusto César Penalva de-
dc.contributor.authorSoares, Alexandre Anderson de Sousa Munhoz-
dc.contributor.authorDescoteaux, Maxime-
dc.contributor.authorRegattieri, Neysa Aparecida Tinoco-
dc.date.accessioned2024-09-20T15:46:26Z-
dc.date.available2024-09-20T15:46:26Z-
dc.date.issued2023-
dc.identifier.citationBISPO, Diógenes Diego de Carvalho et al. Altered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractography. Scientific Reports, [S. l.], v. 13, art. n.12886, 2023. DOI: https://doi.org/10.1038/s41598-023-40115-7. Disponível em: 20 set. 2024.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/50397-
dc.language.isoengpt_BR
dc.publisherSpringer Naturept_BR
dc.rightsAcesso Abertopt_BR
dc.titleAltered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractographypt_BR
dc.typeArtigopt_BR
dc.subject.keywordDisfunção olfativapt_BR
dc.subject.keywordCovid-19pt_BR
dc.rights.license(CC BY) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/ by/4.0/.-
dc.identifier.doihttps://doi.org/10.1038/s41598-023-40115-7pt_BR
dc.description.abstract1We aimed to investigate changes in olfactory bulb volume and brain network in the white matter (WM) in patients with persistent olfactory disfunction (OD) following COVID‑19. A cross‑sectional study evaluated 38 participants with OD after mild COVID‑19 and 24 controls, including Sniffin’ Sticks identification test (SS‑16), MoCA, and brain magnetic resonance imaging. Network‑Based Statistics (NBS) and graph theoretical analysis were used to explore the WM. The COVID‑19 group had reduced olfactory bulb volume compared to controls. In NBS, COVID‑19 patients showed increased structural connectivity in a subnetwork comprising parietal brain regions. Regarding global network topological properties, patients exhibited lower global and local efficiency and higher assortativity than controls. Concerning local network topological properties, patients had reduced local efficiency (left lateral orbital gyrus and pallidum), increased clustering (left lateral orbital gyrus), increased nodal strength (right anterior orbital gyrus), and reduced nodal strength (left amygdala). SS‑16 test score was negatively correlated with clustering of whole‑brain WM in the COVID‑19 group. Thus, patients with OD after COVID‑19 had relevant WM network dysfunction with increased connectivity in the parietal sensory cortex. Reduced integration and increased segregation are observed within olfactory‑related brain areas might be due to compensatory plasticity mechanisms devoted to recovering olfactory function.pt_BR
dc.contributor.affiliationUniversity of Brasilia, Brasilia University Hospital, Diagnostic Imaging Unitpt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasilia, Neuroscience and Behavior Labpt_BR
dc.contributor.affiliationHospital Sírio-Libanês, Brasíliapt_BR
dc.contributor.affiliationBrazilian Institute of Neuropsychology and Cognitive Sciences, Advanced Psychometry Laboratorypt_BR
dc.contributor.affiliationHospital Santa Marta, Department of Radiology, Taguatingapt_BR
dc.contributor.affiliationHospital Santa Marta, Department of Radiology, Taguatingapt_BR
dc.contributor.affiliationHospital Santa Marta, Department of Radiology, Taguatingapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicinept_BR
dc.contributor.affiliationHospital Sírio-Libanês, Brasíliapt_BR
dc.contributor.affiliationInstituto de Infectologia Emílio Ribas, Department of Neurologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Sherbrooke, Sherbrooke Connectivity Imaging Lab, Sherbrooke, QC, Canadapt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicinept_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeHospital Universitário de Brasília (HUB)-
Aparece nas coleções:Artigos publicados em periódicos e afins
UnB - Covid-19

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.