Título :	Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Autor :	Piau, Tathyana Benetis Rodrigues, Aline de Queiroz Paulini, Fernanda
metadata.dc.identifier.orcid:	https://orcid.org/0000-0003-4490-9614
metadata.dc.contributor.affiliation:	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences
Assunto::	Fertilização in vitro Complexo-cumulus-ovócito Fator de crescimento Foliculogênese
Fecha de publicación :	5-dic-2023
Editorial :	Elsevier
Citación :	PIAU, Tathyana Benetis; RODRIGUES, Aline de Queiroz; PAULINI, Fernanda. Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies. Growth Hormone & IGF Research, [S.l.], v. 72/73, e101561, 2023. DOI: https://doi.org/10.1016/j.ghir.2023.101561. Disponível em: https://www.sciencedirect.com/science/article/pii/S1096637423000394?via%3Dihub. Acesso em: 07 ago. 2025.
Abstract:	The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis. Considering the importance of IGFs in oocyte maturation, this review sought to elucidate aspects including: IGF production mechanisms; constituent members of their family and their respective functions; the role that these factors play during folliculogenesis, together with their functions during oocyte maturation and apoptosis, and their performance during luteal development. This review also explores the role of IGFs in biotechnological applications, focusing specifically on animal genetic gain.
metadata.dc.description.unidade:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Biologia Animal
DOI:	https://doi.org/10.1016/j.ghir.2023.101561
metadata.dc.relation.publisherversion:	https://www.sciencedirect.com/science/article/pii/S1096637423000394?via%3Dihub
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