Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies

Piau, Tathyana Benetis; Rodrigues, Aline de Queiroz; Paulini, Fernanda

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Piau, Tathyana Benetis	-
dc.contributor.author	Rodrigues, Aline de Queiroz	-
dc.contributor.author	Paulini, Fernanda	-
dc.date.accessioned	2025-09-19T11:30:33Z	-
dc.date.available	2025-09-19T11:30:33Z	-
dc.date.issued	2023-12-05	-
dc.identifier.citation	PIAU, Tathyana Benetis; RODRIGUES, Aline de Queiroz; PAULINI, Fernanda. Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies. Growth Hormone & IGF Research, [S.l.], v. 72/73, e101561, 2023. DOI: https://doi.org/10.1016/j.ghir.2023.101561. Disponível em: https://www.sciencedirect.com/science/article/pii/S1096637423000394?via%3Dihub. Acesso em: 07 ago. 2025.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/52467	-
dc.language.iso	eng	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Fertilização in vitro	pt_BR
dc.subject.keyword	Complexo-cumulus-ovócito	pt_BR
dc.subject.keyword	Fator de crescimento	pt_BR
dc.subject.keyword	Foliculogênese	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.ghir.2023.101561	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1096637423000394?via%3Dihub	pt_BR
dc.description.abstract1	The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis. Considering the importance of IGFs in oocyte maturation, this review sought to elucidate aspects including: IGF production mechanisms; constituent members of their family and their respective functions; the role that these factors play during folliculogenesis, together with their functions during oocyte maturation and apoptosis, and their performance during luteal development. This review also explores the role of IGFs in biotechnological applications, focusing specifically on animal genetic gain.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0003-4490-9614	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences	pt_BR
dc.description.unidade	Instituto de Ciências Biológicas (IB)	pt_BR
dc.description.unidade	Departamento de Ciências Fisiológicas (IB CFS)	pt_BR
dc.description.ppg	Programa de Pós-Graduação em Biologia Animal	pt_BR
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