Título:	microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers
Autor(es):	Almeida, Ricardo Titze de Almeida, Simoneide Souza Titze de Ferreira, Gabriel Ginani Silva, Andrezza Paula Brito Brandão, Pedro Renato de Paula Oertel, Wolfgang H. Schenck, Carlos H. Rodrigues, Raimundo Nonato Delgado
ORCID:	https://orcid.org/0000-0002-5019-4742 https://orcid.org/0000-0002-8024-7403
Afiliação do autor:	University of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory Network for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil University of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory Network for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil University of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory Network for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil Institute of Psychiatry of Brasília, Brasília, DF, Brazil University of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory Network for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil University of Brasília, Laboratory of Neuroscience and Behavior Neurology Clinic, Medical Department, Chamber of Deputies, The National Congress, Brasília, DF, Brazil Philipps University Marburg, Department of Neurology, Marburg, Germany Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical School University of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory Network for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil University of Brasília, Faculty of Medicine, Department of Neurology and Sleep Medicine
Assunto:	MicroRNA Parkinson, Doença de Sono REM Biomarcadores
Data de publicação:	2021
Editora:	Elsevier B. V.
Referência:	TILZE-DE-ALMEIDA, Ricardo et al. microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers. Sleep Medicine, [S. l.], v. 78, p. 160-168, fev. 2021. DOI: https://doi.org/10.1016/j.sleep.2020.12.012.
Abstract:	The flow of gene expression or “The central dogma of molecular biology”: DNA e RNA e protein, pro- posed by Watson & Crick sixty years ago, is a tightly controlled cell process. In the middle of this journey, the mRNA molecule is regulated by “RNA interference” (RNAi), a posttranscriptional gene silencing mechanism. A microRNA is an endogenous short double-stranded RNA that down-regulates hundreds of mRNAs by RNAi, maintaining healthy cell physiology. In contrast, aberrant expressions of microRNAs play a role in Parkinson's disease (PD) pathogenesis. The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood and sleep changes are often manifested. REM-sleep behavior disorder (RBD) is the prodromal manifestation with the highest odds for conversion into PD, thereby a valuable phenotype for disease prediction. The present review focuses on microRNAs' role in the pathogenesis of PD and RBD, summarizing the state-of-the-art of these RNA molecules as noninvasive biomarkers for non-motor prodromal (RBD) and early PD.
Unidade Acadêmica:	Faculdade de Agronomia e Medicina Veterinária (FAV) Faculdade de Medicina (FM)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências da Saúde
DOI:	https://doi.org/10.1016/j.sleep.2020.12.012
Versão da editora:	https://www.sciencedirect.com/science/article/pii/S1389945720305621?via%3Dihub
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