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dc.contributor.authorAlmeida, Ricardo Titze de-
dc.contributor.authorAlmeida, Simoneide Souza Titze de-
dc.contributor.authorFerreira, Gabriel Ginani-
dc.contributor.authorSilva, Andrezza Paula Brito-
dc.contributor.authorBrandão, Pedro Renato de Paula-
dc.contributor.authorOertel, Wolfgang H.-
dc.contributor.authorSchenck, Carlos H.-
dc.contributor.authorRodrigues, Raimundo Nonato Delgado-
dc.date.accessioned2024-11-25T13:32:27Z-
dc.date.available2024-11-25T13:32:27Z-
dc.date.issued2021-
dc.identifier.citationTILZE-DE-ALMEIDA, Ricardo et al. microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers. Sleep Medicine, [S. l.], v. 78, p. 160-168, fev. 2021. DOI: https://doi.org/10.1016/j.sleep.2020.12.012.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51008-
dc.language.isoengpt_BR
dc.publisherElsevier B. V.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titlemicroRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkerspt_BR
dc.typeArtigopt_BR
dc.subject.keywordMicroRNApt_BR
dc.subject.keywordParkinson, Doença dept_BR
dc.subject.keywordSono REMpt_BR
dc.subject.keywordBiomarcadorespt_BR
dc.identifier.doihttps://doi.org/10.1016/j.sleep.2020.12.012pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1389945720305621?via%3Dihubpt_BR
dc.description.abstract1The flow of gene expression or “The central dogma of molecular biology”: DNA e RNA e protein, pro- posed by Watson & Crick sixty years ago, is a tightly controlled cell process. In the middle of this journey, the mRNA molecule is regulated by “RNA interference” (RNAi), a posttranscriptional gene silencing mechanism. A microRNA is an endogenous short double-stranded RNA that down-regulates hundreds of mRNAs by RNAi, maintaining healthy cell physiology. In contrast, aberrant expressions of microRNAs play a role in Parkinson's disease (PD) pathogenesis. The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood and sleep changes are often manifested. REM-sleep behavior disorder (RBD) is the prodromal manifestation with the highest odds for conversion into PD, thereby a valuable phenotype for disease prediction. The present review focuses on microRNAs' role in the pathogenesis of PD and RBD, summarizing the state-of-the-art of these RNA molecules as noninvasive biomarkers for non-motor prodromal (RBD) and early PD.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5019-4742pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8024-7403pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazilpt_BR
dc.contributor.affiliationInstitute of Psychiatry of Brasília, Brasília, DF, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Neuroscience and Behaviorpt_BR
dc.contributor.affiliationNeurology Clinic, Medical Department, Chamber of Deputies, The National Congress, Brasília, DF, Brazilpt_BR
dc.contributor.affiliationPhilipps University Marburg, Department of Neurology, Marburg, Germanypt_BR
dc.contributor.affiliationMinnesota Regional Sleep Disorders Center, Departments of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical Schoolpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratorypt_BR
dc.contributor.affiliationNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazilpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Department of Neurology and Sleep Medicinept_BR
dc.description.unidadeFaculdade de Agronomia e Medicina Veterinária (FAV)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências da Saúdept_BR
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