Título :	Follicle-targeted delivery of betamethasone and minoxidil co-entrapped in polymeric and lipid nanoparticles for topical alopecia areata treatment
Autor :	Matos, Breno Noronha Lima, Ana Luiza Cardoso, Camila Oliveira Cunha Filho, Marcílio Sérgio Soares da Gratieri, Taís Gelfuso, Guilherme Martins
metadata.dc.identifier.orcid:	https://orcid.org/0009-0007-9366-1260 https://orcid.org/0000-0002-2177-8941 https://orcid.org/0000-0003-3494-2111 https://orcid.org/0000-0002-9167-6852 https://orcid.org/0000-0001-6481-2364 https://orcid.org/0000-0002-1924-7885
metadata.dc.contributor.affiliation:	University of Brasilia, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Laboratory of Food, Drugs and Cosmetics University of Brasilia, School of Health Sciences
Assunto::	Alopécia Nanotecnologia Folículo capilar Nanopartículas Minoxidil Alopecia areata Betametasona
Fecha de publicación :	19-sep-2023
Citación :	MATOS, Breno N. et al. Follicle-targeted delivery of betamethasone and minoxidil co-entrapped in polymeric and lipid nanoparticles for topical alopecia areata treatment. Pharmaceuticals. [S. l.], v. 16, n. 9, 19 set. 2023. DOI: https://doi.org/10.3390/ph16091322. Disponível em: https://www.mdpi.com/1424-8247/16/9/1322. Acesso em: 25 set. 2024.
Abstract:	Alopecia areata is managed with oral corticosteroids, which has known side effects for patients. Given that a topical application of formulations containing a corticoid and a substance controlling hair loss progression could reduce or eliminate such adverse effects and increase the patient’s adherence to the treatment, this study prepares polymeric and lipidic nanoparticles (PNPs and NLCs) to co-entrap minoxidil and betamethasone and compares the follicular drug delivery provided by topical application of these nanoparticles. The prepared PNPs loaded 99.1 ± 13.0% minoxidil and 70.2 ± 12.8% betamethasone, while the NLCs entrapped 99.4 ± 0.1 minoxidil and 80.7 ± 0.1% betamethasone. PNPs and NLCs presented diameters in the same range, varying from 414 ± 10 nm to 567 ± 30 nm. The thermal analysis revealed that the production conditions favor the solubilization of the drugs in the nanoparticles, preserving their stability. In in vitro permeation studies with porcine skin, PNPs provided a 2.6-fold increase in minoxidil penetration into the follicular casts compared to the control and no remarkable difference in terms of betamethasone; in contrast, NLCs provided a significant (specifically, a tenfold) increase in minoxidil penetration into the hair follicles compared to the control, and they delivered higher concentrations of betamethasone in hair follicles than both PNPs and the control. Neither PNPs nor NLCs promoted transdermal permeation of the drugs to the receptor solution, which should favor a topical therapy. Furthermore, both nanoparticles targeted approximately 50% of minoxidil delivery to the follicular casts and NLCs targeted 74% of betamethasone delivery to the hair follicles. In conclusion, PNPs and NLCs are promising drug delivery systems for enhancing follicular targeting of drugs, but NLCs showed superior performance for lipophilic drugs.
metadata.dc.description.unidade:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências da Saúde
Licença::	https://creativecommons.org/licenses/by/4.0/
DOI:	https://doi.org/10.3390/ph16091322
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