Título :	Effects of caffeine on behavioural and cognitive deficits in rats
Autor :	Assis, Melissa Sousa de Soares, Aluízio Carlos Sousa, Dircilei Nascimento de Eudes Filho, João Faro, Lilian Rosana F. Carneiro, Fabiana Pirani Silva, Mônica Valero da Motoyama, Andrea Barreto Souza, Greice Maria R. Marchiori, Stéphanie Lima, Nadyelle Targino Barros, Raphael Boëchat Ferreira, Vania Maria Moraes
metadata.dc.contributor.affiliation:	University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Vigo, Faculty of Biology, Department of Functional Biology and Health Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences University of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciences
Assunto::	Cafeína Comportamento Déficit congnitivo Sepse
Fecha de publicación :	7-may-2018
Editorial :	Wiley
Citación :	ASSIS, Melissa S. et al. Effects of caffeine on behavioural and cognitive deficits in rats. Basic & Clinical Pharmacology & Toxicology, [S. l.], v. 123, p. 435-442, 2018. DOI: https://doi.org/10.1111/bcpt.13036.
Abstract:	There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the caecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity. This procedure, which served to generate experimental sepsis, is herein referred to as ceccum ligation and perforation (CLP). The caffeine (10 mg/kg) was administered by gavage route, once daily, during 7 or 14 consecutive days to investigate the effects of acute or subchronic caffeine treatment on long term behavioural and cognitive deficits induced by CLP. On the last day, 1 hr after caffeine administration, the animals were submitted to open-field, elevated plus maze (EPM), forced swimming and step-down inhibitory avoidance tests. The results showed that caffeine increased the percentage of open arm entries and open arm time in the EPM test, and reduced the immobil ity time when compared to the sham-operated group. The caffeine also increased the latency in the inhibitory avoidance test plat form. Our results demonstrated that the caffeine improved behavioural changes and improved the neurocognitive deficits of sepsis-surviving animals. It is possible that blockage of the adenosine receptors may be responsible for the results here observed.
metadata.dc.description.unidade:	Faculdade de Medicina (FM) Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências Médicas
DOI:	https://doi.org/10.1111/bcpt.13036
metadata.dc.relation.publisherversion:	https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13036
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