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Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/47429
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dc.contributor.authorAssis, Melissa Sousa de-
dc.contributor.authorSoares, Aluízio Carlos-
dc.contributor.authorSousa, Dircilei Nascimento de-
dc.contributor.authorEudes Filho, João-
dc.contributor.authorFaro, Lilian Rosana F.-
dc.contributor.authorCarneiro, Fabiana Pirani-
dc.contributor.authorSilva, Mônica Valero da-
dc.contributor.authorMotoyama, Andrea Barreto-
dc.contributor.authorSouza, Greice Maria R.-
dc.contributor.authorMarchiori, Stéphanie-
dc.contributor.authorLima, Nadyelle Targino-
dc.contributor.authorBarros, Raphael Boëchat-
dc.contributor.authorFerreira, Vania Maria Moraes-
dc.date.accessioned2024-01-22T14:44:40Z-
dc.date.available2024-01-22T14:44:40Z-
dc.date.issued2018-05-07-
dc.identifier.citationASSIS, Melissa S. et al. Effects of caffeine on behavioural and cognitive deficits in rats. Basic & Clinical Pharmacology & Toxicology, [S. l.], v. 123, p. 435-442, 2018. DOI: https://doi.org/10.1111/bcpt.13036.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47429-
dc.language.isoengpt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleEffects of caffeine on behavioural and cognitive deficits in ratspt_BR
dc.typeArtigopt_BR
dc.subject.keywordCafeínapt_BR
dc.subject.keywordComportamentopt_BR
dc.subject.keywordDéficit congnitivopt_BR
dc.subject.keywordSepsept_BR
dc.identifier.doihttps://doi.org/10.1111/bcpt.13036pt_BR
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13036pt_BR
dc.description.abstract1There are many studies that have sought to find drug therapies to prevent harm arising from sepsis. Such studies have represented a progress in the support to septic patients and also in the development of new pharmacological alternatives. Our interest was to investigate the caffeine effect on sepsis behavioural and memory impairments. Male rats were anaesthetized and the surgery was made to allow exposure of the caecum, which was then squeezed to extrude a small amount of faeces from the perforation site, which was later placed back into the peritoneal cavity. This procedure, which served to generate experimental sepsis, is herein referred to as ceccum ligation and perforation (CLP). The caffeine (10 mg/kg) was administered by gavage route, once daily, during 7 or 14 consecutive days to investigate the effects of acute or subchronic caffeine treatment on long term behavioural and cognitive deficits induced by CLP. On the last day, 1 hr after caffeine administration, the animals were submitted to open-field, elevated plus maze (EPM), forced swimming and step-down inhibitory avoidance tests. The results showed that caffeine increased the percentage of open arm entries and open arm time in the EPM test, and reduced the immobil ity time when compared to the sham-operated group. The caffeine also increased the latency in the inhibitory avoidance test plat form. Our results demonstrated that the caffeine improved behavioural changes and improved the neurocognitive deficits of sepsis-surviving animals. It is possible that blockage of the adenosine receptors may be responsible for the results here observed.pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Vigo, Faculty of Biology, Department of Functional Biology and Health Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Postgraduate Program in Medical Sciencespt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Médicaspt_BR
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