Title:	Innovative treatments for epilepsy : venom peptides, cannabinoids, and neurostimulation
Authors:	Lima, Larissa Silva de Loyola, Vinícius Bicca, João Victor Montenegro Luzardo Faro, Lucas Vale, Camilla Lepesqueur Costa Denucci, Bruna Lotufo Mortari, Márcia Renata
metadata.dc.contributor.email:	mailto:mmortari@unb.br
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-7050-5560 https://orcid.org/0000-0002-6849-6001
Assunto::	Epilepsia Neuroestimulação Canabidiol Fármacos antiepilépticos
Issue Date:	7-Aug-2022
Publisher:	Wiley
Citation:	LIMA, Larissa Silva de et. al. Innovative treatments for epilepsy: venom peptides, cannabinoids, and neurostimulation. Journal of Neuroscience Research, v. 100, n. 11, p. 1969-1986, nov. 2022. DOI https://doi.org/10.1002/jnr.25114. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114. Acesso em: 28 ago. 2023.
Abstract:	Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug-resistant patients who are not eligible for palliative surgeries.
metadata.dc.description.unidade:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS)
DOI:	https://doi.org/10.1002/jnr.25114
metadata.dc.relation.publisherversion:	https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114
Agência financiadora:	UnB - Edital DPI/DPG n. 02/2022
Appears in Collections:	Artigos publicados em periódicos e afins

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