Innovative treatments for epilepsy : venom peptides, cannabinoids, and neurostimulation

Lima, Larissa Silva de; Loyola, Vinícius; Bicca, João Victor Montenegro Luzardo; Faro, Lucas; Vale, Camilla Lepesqueur Costa; Denucci, Bruna Lotufo; Mortari, Márcia Renata

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Campo DC	Valor	Idioma
dc.contributor.author	Lima, Larissa Silva de	-
dc.contributor.author	Loyola, Vinícius	-
dc.contributor.author	Bicca, João Victor Montenegro Luzardo	-
dc.contributor.author	Faro, Lucas	-
dc.contributor.author	Vale, Camilla Lepesqueur Costa	-
dc.contributor.author	Denucci, Bruna Lotufo	-
dc.contributor.author	Mortari, Márcia Renata	-
dc.date.accessioned	2023-08-28T19:02:30Z	-
dc.date.available	2023-08-28T19:02:30Z	-
dc.date.issued	2022-08-07	-
dc.identifier.citation	LIMA, Larissa Silva de et. al. Innovative treatments for epilepsy: venom peptides, cannabinoids, and neurostimulation. Journal of Neuroscience Research, v. 100, n. 11, p. 1969-1986, nov. 2022. DOI https://doi.org/10.1002/jnr.25114. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114. Acesso em: 28 ago. 2023.	pt_BR
dc.identifier.uri	http://repositorio2.unb.br/jspui/handle/10482/46410	-
dc.description.sponsorship	UnB - Edital DPI/DPG n. 02/2022	pt_BR
dc.language.iso	eng	pt_BR
dc.publisher	Wiley	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Innovative treatments for epilepsy : venom peptides, cannabinoids, and neurostimulation	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Epilepsia	pt_BR
dc.subject.keyword	Neuroestimulação	pt_BR
dc.subject.keyword	Canabidiol	pt_BR
dc.subject.keyword	Fármacos antiepilépticos	pt_BR
dc.identifier.doi	https://doi.org/10.1002/jnr.25114	pt_BR
dc.relation.publisherversion	https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114	pt_BR
dc.description.abstract1	Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug-resistant patients who are not eligible for palliative surgeries.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-7050-5560	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-6849-6001	pt_BR
dc.contributor.email	mailto:mmortari@unb.br	pt_BR
dc.description.unidade	Instituto de Ciências Biológicas (IB)	pt_BR
dc.description.unidade	Departamento de Ciências Fisiológicas (IB CFS)	pt_BR
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