Título:	The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets
Autor(es):	Arruda, Sandra Fernandes Ramos, Larissa Valadares Barbosa, Júlia Lima de Alencar Hankins, Natália Aboudib Campos Rodrigues, Pedro Augusto Matos Cunha, Marcela de Sá Barreto da
Assunto:	Tucum Hepcidina Proteínas Ferro
Data de publicação:	22-Mai-2020
Editora:	MDPI
Referência:	ARRUDA, Sandra Fernandes et al. The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets. Nutrients, v. 12, n. 5, 1515, 2020. DOI: https://doi.org/10.3390/nu12051515. Disponível em: https://www.mdpi.com/2072-6643/12/5/1515. Acesso em: 23 nov. 2021.
Abstract:	The Brazilian savanna fruit, tucum-do-cerrado (Bactris setosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tucum-do-cerrado (Tuc); iron-enriched diet (+Fe); or iron-enriched diet +15% tucum-do-cerrado (Tuc+Fe). Tucum-do-cerrado (Tuc) decreased hepatic Hamp and Hjv mRNA levels but did not alter Bmp6, Smad7, Tfr1, and Hfe mRNA levels; pSMAD1/5/8 and pSTAT3 protein levels; labile iron pool (LIP); and inflammatory biomarkers, compared to the CT group. The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group. The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group. Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content. However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Nutrição (FS NUT) Instituto de Física (IF)
Programa de pós-graduação:	Programa de Pós-Graduação em Nutrição Humana
Licença:	(CC BY) © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
DOI:	https://doi.org/10.3390/nu12051515
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