| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Arruda, Sandra Fernandes | - |
| dc.contributor.author | Ramos, Larissa Valadares | - |
| dc.contributor.author | Barbosa, Júlia Lima de Alencar | - |
| dc.contributor.author | Hankins, Natália Aboudib Campos | - |
| dc.contributor.author | Rodrigues, Pedro Augusto Matos | - |
| dc.contributor.author | Cunha, Marcela de Sá Barreto da | - |
| dc.date.accessioned | 2021-11-24T15:47:51Z | - |
| dc.date.available | 2021-11-24T15:47:51Z | - |
| dc.date.issued | 2020-05-22 | - |
| dc.identifier.citation | ARRUDA, Sandra Fernandes et al. The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets. Nutrients, v. 12, n. 5, 1515, 2020. DOI: https://doi.org/10.3390/nu12051515. Disponível em: https://www.mdpi.com/2072-6643/12/5/1515. Acesso em: 23 nov. 2021. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/42425 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Tucum | pt_BR |
| dc.subject.keyword | Hepcidina | pt_BR |
| dc.subject.keyword | Proteínas | pt_BR |
| dc.subject.keyword | Ferro | pt_BR |
| dc.rights.license | (CC BY) © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/nu12051515 | pt_BR |
| dc.description.abstract1 | The Brazilian savanna fruit, tucum-do-cerrado (Bactris setosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tucum-do-cerrado (Tuc); iron-enriched diet (+Fe); or iron-enriched diet +15% tucum-do-cerrado (Tuc+Fe). Tucum-do-cerrado (Tuc) decreased hepatic Hamp and Hjv mRNA levels but did not alter Bmp6, Smad7, Tfr1, and Hfe mRNA levels; pSMAD1/5/8 and pSTAT3 protein levels; labile iron pool (LIP); and inflammatory biomarkers, compared to the CT group. The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group. The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group. Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content. However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado. | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | - |
| dc.description.unidade | Departamento de Nutrição (FS NUT) | - |
| dc.description.unidade | Instituto de Física (IF) | - |
| dc.description.ppg | Programa de Pós-Graduação em Nutrição Humana | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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