Title:	Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
Authors:	Araujo, Felipe Saldanha de Melgaço Garcez, Emãnuella Carvalho, Amandda Évelin Silva de Carvalho, Juliana Lott de
Assunto::	Covid-19 Células-tronco mesenquimais Terapia com células-tronco SARS-CoV-2 Ensaios clínicos
Issue Date:	3-Jul-2020
Publisher:	Frontiers
Citation:	SALDANHA-ARAUJO, Felipe et al. Mesenchymal stem cells: a new piece in the puzzle of COVID-19 treatment. Frontiers in Immunology, v. 11, 1563, 2020. DOI: https://doi.org/10.3389/fimmu.2020.01563. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01563/full. Acesso em: 14 out. 2020.
Abstract:	COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underlying the application of stem cells to manage COVID-19, and also a comprehensive compendium of the 69 clinical trials underway worldwide aiming to investigate the application of stem cells to treat COVID-19. Even though data are still scarce, it is already possible to observe the protagonism of China in testing mesenchymal stem cells (MSCs) for COVID-19. Furthermore, it is possible to determine that current efforts focus on the use of multiple infusions of high numbers of stem cells and derived products, as well as to acknowledge the positive results obtained by independent groups who publicized the therapeutic benefits provided by such therapies in 51 COVID-19 patients. In such a rapid-paced field, up-to-date systematic studies and meta-analysis will aid the scientific community to separate hype from hope and offer an unbiased position to the society and governments.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD) Faculdade de Ciências da Saúde (FS)
Licença::	Copyright © 2020 Saldanha-Araujo, Melgaço Garcez, Silva-Carvalho and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fimmu.2020.01563
metadata.dc.relation.isbasedon:	https://repositorio.unb.br/handle/10482/42137
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Covid-19

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