Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment

Araujo, Felipe Saldanha de; Melgaço Garcez, Emãnuella; Carvalho, Amandda Évelin Silva de; Carvalho, Juliana Lott de

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Campo DC	Valor	Idioma
dc.contributor.author	Araujo, Felipe Saldanha de	-
dc.contributor.author	Melgaço Garcez, Emãnuella	-
dc.contributor.author	Carvalho, Amandda Évelin Silva de	-
dc.contributor.author	Carvalho, Juliana Lott de	-
dc.date.accessioned	2020-10-14T14:15:14Z	-
dc.date.available	2020-10-14T14:15:14Z	-
dc.date.issued	2020-07-03	-
dc.identifier.citation	SALDANHA-ARAUJO, Felipe et al. Mesenchymal stem cells: a new piece in the puzzle of COVID-19 treatment. Frontiers in Immunology, v. 11, 1563, 2020. DOI: https://doi.org/10.3389/fimmu.2020.01563. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01563/full. Acesso em: 14 out. 2020.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/39544	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Frontiers	pt_BR
dc.relation.isbasedon	https://repositorio.unb.br/handle/10482/42137	-
dc.rights	Acesso Aberto	pt_BR
dc.title	Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Covid-19	pt_BR
dc.subject.keyword	Células-tronco mesenquimais	pt_BR
dc.subject.keyword	Terapia com células-tronco	pt_BR
dc.subject.keyword	SARS-CoV-2	pt_BR
dc.subject.keyword	Ensaios clínicos	pt_BR
dc.rights.license	Copyright © 2020 Saldanha-Araujo, Melgaço Garcez, Silva-Carvalho and Carvalho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.	pt_BR
dc.identifier.doi	https://doi.org/10.3389/fimmu.2020.01563	pt_BR
dc.description.abstract1	COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underlying the application of stem cells to manage COVID-19, and also a comprehensive compendium of the 69 clinical trials underway worldwide aiming to investigate the application of stem cells to treat COVID-19. Even though data are still scarce, it is already possible to observe the protagonism of China in testing mesenchymal stem cells (MSCs) for COVID-19. Furthermore, it is possible to determine that current efforts focus on the use of multiple infusions of high numbers of stem cells and derived products, as well as to acknowledge the positive results obtained by independent groups who publicized the therapeutic benefits provided by such therapies in 51 COVID-19 patients. In such a rapid-paced field, up-to-date systematic studies and meta-analysis will aid the scientific community to separate hype from hope and offer an unbiased position to the society and governments.	pt_BR
dc.description.unidade	Faculdade de Medicina (FMD)	pt_BR
dc.description.unidade	Faculdade de Ciências da Saúde (FS)	pt_BR
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