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dc.contributor.authorIllanes Tormena, Renata Pascoal-
dc.contributor.authorSantos, Mac-Kedson Medeiros Salviano-
dc.contributor.authorSilva, Atailson Oliveira da-
dc.contributor.authorFélix, Felipe Mourthé-
dc.contributor.authorChaker, Juliano Alexandre-
dc.contributor.authorFreire, Daniel Oliveira-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.contributor.authorMoya, Sergio Enrique-
dc.contributor.authorSousa, Marcelo Henrique-
dc.date.accessioned2026-05-08T13:11:06Z-
dc.date.available2026-05-08T13:11:06Z-
dc.date.issued2024-06-
dc.identifier.citationTORMENA, Renata Pascoal Illanes et al. Enhancing the antimicrobial activity of silver nanoparticles against pathogenic bacteria by using Pelargonium sidoides DC extract in microwave assisted green synthesis. RSC Advances, [S. l.], v. 14, 22035, 2024. DOI: https://doi.org/10.1039/D4RA04140B. Disponível em: https://pubs.rsc.org/en/content/articlehtml/2024/ra/d4ra04140b. Acesso em: 7 mai. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54342-
dc.language.isoengpt_BR
dc.publisherRoyal Society of Chemistrypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEnhancing the antimicrobial activity of silver nanoparticles against pathogenic bacteria by using Pelargonium sidoides DC extract in microwave assisted green synthesispt_BR
dc.typeArtigopt_BR
dc.subject.keywordNanopartículas de pratapt_BR
dc.subject.keywordAtividade antimicrobianapt_BR
dc.subject.keywordSíntese verdept_BR
dc.rights.licenseThis Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licencept_BR
dc.identifier.doihttps://doi.org/10.1039/D4RA04140Bpt_BR
dc.description.abstract1This study presents an optimized microwave-assisted method for the green synthesis of silver nanoparticles (AgNPs) using a root extract obtained from Pelargonium sidoides DC. The influence of temperature, reagent concentration, and irradiation time was systematically investigated to enhance synthesis yield. Characterization techniques including XRD, UV-vis, FTIR, XPS, and zetametry were employed to confirm the successful formation of nanoparticles with a metallic silver core (∼17 nm) functionalized with organic molecules derived from the plant extract. The cytotoxicity of AgNPs was assessed using a cell viability assay, while the Minimum Inhibitory Concentration (MIC) of nanoformulation against pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and the carbapenem-resistant Klebsiella pneumoniae (KPC), was determined using the Broth microdilution method. The nanoformulation synthesized with P. sidoides extract exhibited a dose-dependent response, demonstrating superior antimicrobial efficacy compared to the pure plant extract in most cases. The MIC values ranged from 0.85 to 17.1 μg mL−1, with particularly strong performance against the drug resistant KPC strain. The enhanced antimicrobial effect is attributed to the synergistic action of the metallic silver core and phytochemicals from P. sidoides on the surface of nanoparticles, which also contribute to notable colloidal stability of AgNPs at physiological pH levels.pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-3248-1286pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-6964-3002pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-7434-6491pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-1586-7961pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-1577-7862pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-6836-3583pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7174-1960pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-1210-8329pt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilandia, Graduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Ceilandia, Graduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationCIC biomaGUNE, Soft Matter Nanotechnology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasilia, Green Nanotechnology Grouppt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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