Title:	Respiratory sarcopenia screening in dialysis patients : cross-sectional and multicentre study protocol
Authors:	Andrade, Francini Porcher Borges, Sheila Silva Filho, César Alencar da Martins, Taís Ferreira Benvenutti, Heloíse Freitas, Júlia de Melo Cardoso de Thomé, Fernando Saldanha Karohl, Cristina Souza, Gabriela Correa Cipriano, Graziella França Bernardelli Rovedder, Paula Maria Eidt
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-7673-4241 https://orcid.org/0009-0009-9227-8061 https://orcid.org/0009-0006-8548-5079 https://orcid.org/0000-0001-9560-6520
metadata.dc.contributor.affiliation:	Federal University of Rio Grande do Sul, Ciências Pneumológicas Post-Graduation Programme Hospital de Clínicas de Porto Alegre University of Maia, Health Sciences and Human Development, Research Center in Sports Sciences University of Brasília, Science and Technology in Health Programme Federal University of Rio Grande do Sul, Ciências Pneumológicas Post-Graduation Programme Hospital de Clínicas de Porto Alegre University of Brasília, Sciences of Rehabilitation Post-Graduation Programme Federal University of Rio Grande do Sul, Ciências Pneumológicas Post-Graduation Programme Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul, Medical Sciences Focused on Endocrinology Post-Graduation Programme Federal University of Rio Grande do Sul, Faculty of Medicine Instituto de Doenças Renais, Porto Alegre Federal University of Rio Grande do Sul, Faculty of Medicine Hospital de Clínicas de Porto Alegre Federal University of Rio Grande do Sul, Medical School, Graduate Program in Food, Nutrition and Health University of Brasília, Science and Technology in Health Programme University of Brasília, Sciences of Rehabilitation Post-Graduation Programme Federal University of Rio Grande do Sul, Ciências Pneumológicas Post-Graduation Programme Hospital de Clínicas de Porto Alegre
Assunto::	Doença renal crônica Sarcopenia Função respiratória Hemodiálise - pacientes Diálise peritoneal Pulmão
Issue Date:	29-Jan-2024
Publisher:	Springer Nature
Citation:	ANDRADE, Francini Porcher et al. Respiratory sarcopenia screening in dialysis patients: cross-sectional and multicentre study protocol. BMC Nephrology, [S.l.], v. 25, n. 41, 2024. DOI: https://doi.org/10.1186/s12882-023-03390-0. Disponível em: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-023-03390-0. Acesso em: 08 ago. 2025.
Abstract:	Background Respiratory sarcopenia is characterized by the weakness of respiratory muscles associated with sarcopenia due to aging or systemic diseases such as chronic kidney disease (CKD). Patients with CKD undergoing dialysis are particularly susceptible to respiratory muscle weakness caused by factors such as fuid overload and electrolyte imbalance. This weakness not only afects ventilation but also impairs oxygen uptake and delivery to muscle tissue, potentially leading to severe sarcopenia. Thus, the objective of this study is to conduct a respiratory sarcopenia screening in patients with CKD undergoing haemodialysis (HD) and peritoneal dialysis (PD). Methods This is an observational, cross-sectional and multicentre study conducted between March 2023 and March 2025. The study was approved by the Research Ethics Committee at two centres. Sarcopenia diagnosis is determined based on low handgrip strength and amount of appendicular skeletal muscle mass, assessed through bioelectrical impedance analysis. Respiratory sarcopenia is diagnosed in patients with sarcopenia who have low inspiratory muscle strength, evaluated through a manovacuometry test. The severity of sarcopenia and respiratory sarcopenia is defned, respectively, by low physical performance (measured using the Short Physical Performance Battery and Timed-Up and Go test) and pulmonary performance (measured through spirometry). Thus, this study will include 81 patients undergoing dialysis (41 on HD and 40 on PD) from three participating centres. Discussion The literature has been focused on respiratory function in CKD; however, the relationship with sarcopenia remains understudied. We believe that, similar to appendicular skeleton muscles, the axial skeleton muscles are also likely to weaken with the presence of chronic disease, such as CKD.
metadata.dc.description.unidade:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências da Reabilitação Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença::	© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
DOI:	https://doi.org/10.1186/s12882-023-03390-0
Appears in Collections:	Artigos publicados em periódicos e afins

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