Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/52506
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_UnravelinSARS-CoV-2Spike.pdf1,8 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorBezerra, Filipe Menezes-
dc.contributor.authorPalmeira, Julys da Fonseca-
dc.contributor.authorOliveira, Juliana dos Santos-
dc.contributor.authorArgañaraz, Gustavo Adolfo-
dc.contributor.authorSoares, Carlos Roberto Jorge-
dc.contributor.authorNóbrega, Otávio de Toledo-
dc.contributor.authorRibeiro, Bergmann Morais-
dc.contributor.authorArgañaraz, Enrique Roberto-
dc.date.accessioned2025-09-25T12:02:05Z-
dc.date.available2025-09-25T12:02:05Z-
dc.date.issued2024-12-17-
dc.identifier.citationBEZERRA, Filipe Menezes et al. Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC. Frontiers in Cellular Neuroscience, v. 18, art. 1481963, 2024. DOI: https://doi.org/10.3389/fncel.2024.1481963. Disponível em: https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1481963/full. Acesso em: 03 jul. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/52506-
dc.language.isoengpt_BR
dc.publisherFrontierspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleUnraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASCpt_BR
dc.typeArtigopt_BR
dc.subject.keywordCovid-19 - fisiopatologiapt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordBarreira hematoencefálicapt_BR
dc.rights.license© 2024 Menezes, Palmeira, Oliveira, Argañaraz, Soares, Nóbrega, Ribeiro and Argañaraz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_BR
dc.identifier.doihttps://doi.org/10.3389/fncel.2024.1481963pt_BR
dc.description.abstract1The persistence or emergence of long-term symptoms following resolution of primary SARS-CoV-2 infection is referred to as long COVID or post-acute sequelae of COVID-19 (PASC). PASC predominantly affects the cardiovascular, neurological, respiratory, gastrointestinal, reproductive, and immune systems. Among these, the central nervous system (CNS) is significantly impacted, leading to a spectrum of symptoms, including fatigue, headaches, brain fog, cognitive impairment, anosmia, hypogeusia, neuropsychiatric symptoms, and peripheral neuropathy (neuro-PASC). However, the risk factors and pathogenic mechanisms responsible for neuro-PASC remain unclear. This review hypothesis discusses the leading hypotheses regarding the pathophysiological mechanisms involved in long COVID/PASC, focusing on neuro-PASC. We propose vascular dysfunction mediated by activation of astrocytes and pericytes followed by blood–brain barrier (BBB) disruption as underlying pathophysiological mechanisms of neurological manifestations. Additionally, we provide insights into the role of spike protein at the blood–brain interface. Finally, we explore the potential pathogenic mechanisms initiated by the interaction between the spike protein and cellular receptors at the brain endothelial and tissue levels.pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0001-7830-0447pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2724-369Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1612-2411pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7982-1789pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1775-7176pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1061-196Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4359-7594pt_BR
dc.contributor.affiliationInstituto de Pesquisas Energéticas e Nucleares, Biotechnology Centerpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Laboratory of Molecular Neurovirologypt_BR
dc.contributor.affiliationInstituto de Pesquisas Energéticas e Nucleares, Biotechnology Centerpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculdade de Medicina, Programa de Pós-graduação em Ciências Médicaspt_BR
dc.contributor.affiliationUniversity of Brasília, Department of Cell Biology, Baculovirus Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Laboratory of Molecular Neurovirologypt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândiapt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Médicaspt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins
UnB - Covid-19

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.