Título:	Manual and alternative therapies as non‑pharmacological interventions for pain and stress control in newborns : a systematic review
Autor(es):	Shayani, Leva Arani Marães, Vera Regina Fernandes da Silva
ORCID:	https://orcid.org/0000-0002-9104-7415 https://orcid.org/0000-0001-6605-0308
Afiliação do autor:	Universidade de Brasília Universidade de Brasília
Assunto:	Recém-nascidos - prematuros Dor Estresse Terapias alternativas
Data de publicação:	13-Set-2022
Editora:	Springer Nature
Referência:	SHAYANI, Leva A.; MARÃES, Vera Regina F. da S. Manual and alternative therapies as non‑pharmacological interventions for pain and stress control in newborns: a systematic review. World Journal of Pediatrics, [S.l.], v. 19, p. 35–47, 2023. DOI: https://doi.org/10.1007/s12519-022-00601-w. Disponível em: https://link.springer.com/article/10.1007/s12519-022-00601-w#rightslink. Acesso em: 11 jun. 2025.
Abstract:	Background Supporting therapies that provide stress and pain control of preterm and term newborns infants contribute positively to the neuropsychomotor development. Non-pharmacological interventions that involve manual techniques are described, considering protocols that can be reproduced by physical therapists, with positive and negative outcomes reports. Data sources Systematic review follows PRISMA 2020 statements guidelines. Primary and specifc health sciences databases (Science Direct, Pubmed, Scielo, Embase and Scopus) were consulted between October 2021 and May 2022. Articles considered were clinical trials, randomized or not, that included descriptions of the type of intervention as non-pharmacological and that studied the following outcomes: “pain” and “stress”. Results Fifteen articles were selected for analysis, reaching a methodological quality of at least 3 on the Jadad Scale for the Quality of Researched Sources. The non-pharmacological therapies most applied in isolation were massage, swaddling or wrapping, gentle touch and kinesthetic stimulation, and the combined therapies were non-nutritive sucking and swaddling, oral sucrose and swaddling, sensory stimulation and familiar odors, and sensory saturation. The outcomes found were relaxation, pain, and stress reduction after the application of painful procedures. The behavioral changes included crying, grimacing, yawning, sneezing, jerky arm or leg movements, startles, and fnger faring. The vital signs included heart rate, blood oxygen saturation level, and pulse respiration. Conclusions Combined techniques lead to better results in controlling neonatal pain when compared to isolated techniques. They can be applied both in preterm and term infants in a safe way and are reproducible in any health unit in a simple and economical way.
Unidade Acadêmica:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
DOI:	https://doi.org/10.1007/s12519-022-00601-w
Versão da editora:	https://link.springer.com/article/10.1007/s12519-022-00601-w#rightslink
Aparece nas coleções:	Artigos publicados em periódicos e afins

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