Title:	MAOA uVNTR genetic variant and major depressive disorder : a systematic review
Authors:	Gonçalves, Ana Beatriz Castro Fratelli, Caroline Ferreira Siqueira, Jhon Willatan Saraiva Duarte, Ligia Canongia de Abreu Cardoso Barros, Aline Ribeiro Possatti, Isabella Santos, Maurício Lima dos Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-6339-8939 https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-6836-3583
metadata.dc.contributor.affiliation:	University of Brasília, Faculty of Ceilândia, Pharmacy Course University of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologies University of Brasília, Faculty of Ceilândia, Pharmacy Course University of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologies University of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologies University of Brasília, Faculty of Ceilândia, Postgraduate Program in Health Sciences and Technologies University of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sector University of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sector University of Brasília, Faculty of Ceilândia, Pharmacy Department, Clinical Analysis Laboratory, Molecular Pathology Sector
Assunto::	Transtorno depressivo maior Monoaminas Polimorfismo genético Farmacogenética
Issue Date:	2022
Publisher:	MDPI
Citation:	GONÇALVES, Ana Beatriz Castro et al. MAOA uVNTR genetic variant and major depressive disorder: a systematic review. Cells, [S. l.], v. 11, n. 20, 3267, 2022. DOI: https://doi.org/10.3390/cells11203267. Disponível em: https://www.mdpi.com/2073-4409/11/20/3267. Acesso em: 03 fev. 2025.
Abstract:	Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand the MAOA uVNTR polymorphism influence on MDD and evaluate its 3R/3R and 3R* genotypic frequencies fluctuation in MDD patients from different populations. We searched the Web of Science, PubMed, Virtual Health Library, and EMBASE databases for eligible original articles that brought data on genotypic frequencies related to the MAOA uVNTR variant in patients with MDD. We excluded studies with incomplete data (including statistical data), reviews, meta-analyses, and abstracts. Initially, we found 43 articles. After removing duplicates and applying the inclusion/exclusion criteria, seven articles remained. The population samples studied were predominantly Asians, with high 3R and 4R allele frequencies. Notably, we observed higher 3R/3R (female) and 3R* (male) genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotype frequencies in the MDD groups in the majority of different populations. Despite some similarities in the articles analyzed, there is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis.
metadata.dc.description.unidade:	Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia Curso de Farmácia (FCTS-FAR)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença::	(CC BY) This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
DOI:	https://doi.org/10.3390/cells11203267
Appears in Collections:	Artigos publicados em periódicos e afins

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