Título :	Biological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana raniceps
Autor :	Santana, Carlos José Correia Magalhães, Ana Carolina Martins Prías Márquez, César Augusto Falico, Diego Alejandro Santos Júnior, Agenor de Castro Moreira dos Lima, Beatriz Dolabela Ricart, Carlos André Ornelas Pilger, Denise Regina Bairros de Bonotto, Rafaela Milan Moraes, Carolina Borsoi Freitas Júnior, Lúcio Holanda de Morales Álvares, Alice da Cunha Freitas, Sônia Maria Luz, Isabelle Souza Pires Júnior, Osmindo Rodrigues Fontes, Wagner Castro, Mariana de Souza
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-9781-3670 https://orcid.org/0000-0002-0689-2770 https://orcid.org/0000-0001-8722-5103 https://orcid.org/0000-0002-9875-9407 https://orcid.org/0000-0001-5140-8573
metadata.dc.contributor.affiliation:	University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of São Paulo, Institute of Biomedical Sciences, Department of Microbiology University of São Paulo, Institute of Biomedical Sciences, Department of Microbiology University of São Paulo, Institute of Biomedical Sciences, Department of Microbiology University of São Paulo, Institute of Biomedical Sciences, Department of Microbiology University of São Paulo, Institute of Biomedical Sciences, Department of Microbiology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysics University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysics University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry University of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry
Assunto::	Anfíbio Secreção cutânea Peptídeos Peptídeos antimicrobianos Neutrófilos
Fecha de publicación :	20-may-2020
Editorial :	MDPI
Citación :	SANTANA, Carlos José Correia et al. Biological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana raniceps. Biomolecules, [S. l.], v. 10, n. 5, 790, 2020. DOI: https://doi.org/10.3390/biom10050790. Disponível em: https://www.mdpi.com/2218-273X/10/5/790. Acesso em: 10 jan. 2025.
Abstract:	In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem. Amphibian skin secretions are a rich source of host defense peptides, which generally are cationic and hydrophobic molecules, with a broad-spectrum of activity. In this study, one novel multifunctional defense peptide was isolated from the skin secretion of the Chaco tree frog, Boana raniceps. Figainin 2 (1FLGAILKIGHALAKTVLPMVTNAFKPKQ28) is cationic and hydrophobic, adopts an α-helical structure in 50% (v/v) trifluoroethanol (TFE), and is thermally stable. This peptide exhibited activity against Gram-negative and Gram-positive pathogenic bacteria arboviruses, T. cruzi epimastigotes; however, it did not show activity against yeasts. Figainin 2 also showed antiproliferative activity on cancer cells, is moderately active on human erythrocytes, and activates the oxidative burst in human neutrophils.
metadata.dc.description.unidade:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS) Departamento de Biologia Celular (IB CEL)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Biologia Animal
DOI:	https://doi.org/10.3390/biom10050790
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