Title:	The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study
Authors:	Santana, Yago Ranniere Teixeira Andrade, Débora Dornelas Belchior Costa Barroso, Daniel Holanda Silva, Andressa Vieira Oliveira, Lucas Felipe Carvalho Timbó, Renata Velôzo Araújo, David Dias Andrade, Rafael Rocha de Pellegrini, Marcos Antonio Carvalho, Fabíola Christian Almeida de Martins, Luciana Pereira Freire Gomes, Ciro Martins
metadata.dc.identifier.orcid:	https://orcid.org/0000-0003-3434-2669 https://orcid.org/0000-0003-1989-7412 https://orcid.org/0000-0001-8594-0015 https://orcid.org/0000-0002-9532-4854 https://orcid.org/0000-0002-3069-6884
metadata.dc.contributor.affiliation:	Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Ministério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI) Universidade de Brasília, Programa de Pós-Graduação em Saúde Coletiva Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Ministério da Saúde do Brasil, Secretaria Especial de Saúde Indígena (SESAI) Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Dimensuri Assessoria Técnica, Brasília Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade Federal de Roraima, Programa de Pós-Graduação em Ciências da Saúde Universidade Federal de Roraima, Programa de Pós-Graduação em Ciências da Saúde Universidade de Brasília, Programa de Pós-Graduação em Patologia Molecular Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília, Programa de Pós-Graduação em Patologia Molecular
Assunto::	Tungíase Indígenas Doenças infecciosas
Issue Date:	25-Oct-2023
Publisher:	MDPI
Citation:	SANTANA, Yago Ranniere Teixeira et al. The effectiveness of topical dimethicone together with a one health approach for the control of tungiasis in the Sanumás communities, Yanomami territory, Amazon rainforest: a real-world study. Tropical Medicine and Infections Diseases, [S. l.], v. 8, n. 11, 489, 2023. DOI: https://doi.org/10.3390/tropicalmed8110489. Disponível em: https://www.mdpi.com/2414-6366/8/11/489. Acesso em: 16 jul. 2024.
Abstract:	Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA®) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA® together with animal and environmental interventions are effective measures for the control of tungiasis.
metadata.dc.description.unidade:	Faculdade de Medicina (FM) Faculdade de Ciências da Saúde (FS) Departamento de Saúde Coletiva (FS SC) Instituto de Ciências Biológicas (IB) Departamento de Biologia Celular (IB CEL)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências Médicas Programa de Pós-Graduação em Saúde Coletiva Programa de Pós-Graduação em Patologia Molecular
Licença::	Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI:	https://doi.org/10.3390/tropicalmed8110489
Appears in Collections:	Artigos publicados em periódicos e afins

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