Title:	Pathology and one health implications of fatal Leptospira interrogansinfection in an urbanized, free-ranging, black-tufted marmoset (Callithrix penicillata) in Brazil
Authors:	Wilson, Tais Meziara Ritter, Jana M. Martines, Roosecelis B. Gonçalves, Alexandra Ariadine Bittencourt Fair, Pamela Galloway, Renee Weiner, Zachary Romano, Alessandro Pecego Martins Costa, Gabriela R. T. Melo, Cristiano Barros de Zaki, Sherif R. Castro, Márcio Botelho de
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-0404-9499 https://orcid.org/0000-0002-5501-7796 https://orcid.org/0000-0002-3996-0856
metadata.dc.contributor.affiliation:	University of Brasília, Veterinary Pathology Laboratory Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA University of Brasília, Graduate Program in Animal Science Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA Technical Group on Arbovirus Surveillance, General Coordination of Communicable Diseases, Department of Communicable Disease Surveillance, Secretariat of Health Surveillance, Brazilian Ministry of Health, Brasilia, Brazil Environmental Health Surveillance Directorate of the Federal District, Brasilia, Brazil University of Brasília, Graduate Program in Animal Science Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA University of Brasília, Veterinary Pathology Laboratory University of Brasília, Graduate Program in Animal Science
Assunto::	Histopatologia Imuno-histoquímica Leptospirose Sagui Zoonoses
Issue Date:	13-Aug-2021
Publisher:	Wiley
Citation:	WILSON, Tais M. et al. Pathology and one health implications of fatal Leptospira interrogans infection in an urbanized, free¿ranging, black¿tufted marmoset (Callithrix penicillata) in Brazil. Transboundary and Emerging Diseases, [S. l.], 13 ago. 2021. DOI: https://doi.org/10.1111/tbed.14287.
Abstract:	Leptospirosis is a zoonotic neglected disease of worldwide public health concern. Lep tospira species can infect a wide range of wild and domestic mammals and lead to a spectrum of disease, including severe and fatal forms. Herein, we report for the first time a fatal Leptospira interrogansinfection in a free-ranging nonhuman primate (NHP), a black-tufted marmoset. Icterus, pulmonary haemorrhage, interstitial nephritis, and hepatocellular dissociation were the main findings raising the suspicion of leptospiro sis. Diagnostic confirmation was based on specific immunohistochemical and PCR assays for Leptospira species. Immunolocalization of leptospiral antigens and identifi cation of pathogenic species (L. interrogans species) were important for better under standing the pathogenesis of the disease. One Health–related implications of free ranging NHPs in anthropized areas and transmission dynamics of human and animal leptospirosis are discussed.
metadata.dc.description.unidade:	Faculdade de Agronomia e Medicina Veterinária (FAV)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciência Animal
DOI:	https://doi.org/10.1111/tbed.14287
metadata.dc.relation.publisherversion:	https://onlinelibrary.wiley.com/doi/10.1111/tbed.14287
Appears in Collections:	Artigos publicados em periódicos e afins

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