| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Santiago, Paula Beatriz | - |
| dc.contributor.author | Bentes, Kaio Luís da Silva | - |
| dc.contributor.author | Silva, Waldeyr Mendes Cordeiro da | - |
| dc.contributor.author | Praça, Yanna Reis | - |
| dc.contributor.author | Charneau, Sébastien | - |
| dc.contributor.author | Soraya Chaouch | - |
| dc.contributor.author | PhilippeGrellier4 | - |
| dc.contributor.author | Marcos Antônio dos Santos Silva Ferraz | - |
| dc.contributor.author | Izabela Marques Dourado Bastos | - |
| dc.contributor.author | Jaime Martins de Santana | - |
| dc.contributor.author | Carla Nunes de Araújo | - |
| dc.date.accessioned | 2024-07-02T11:53:11Z | - |
| dc.date.available | 2024-07-02T11:53:11Z | - |
| dc.date.issued | 2023-08-12 | - |
| dc.identifier.citation | SANTIAGO, Paula Beatriz et al. Insights into the microRNA landscape of Rhodnius prolixus, a vector of Chagas disease. Scientific Reports, [S. l.], v. 13, art. n. 13120, 2023. DOI: https://doi.org/10.1038/s41598-023-40353-9. Disponível em: https://www.nature.com/articles/s41598-023-40353-9. Acesso em: 02 jul. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/48494 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Nature Research | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Insights into the microRNA landscape of Rhodnius prolixus, a vector of Chagas disease | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Vetores | pt_BR |
| dc.subject.keyword | Chagas, Doença de | pt_BR |
| dc.subject.keyword | MicroRNA | pt_BR |
| dc.subject.keyword | Triatomíneos | pt_BR |
| dc.rights.license | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1038/s41598-023-40353-9 | pt_BR |
| dc.description.abstract1 | The growing interest in microRNAs (miRNAs) over recent years has led to their characterization in numerous organisms. However, there is currently a lack of data available on miRNAs from triatomine bugs (Reduviidae: Triatominae), which are the vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. A comprehensive understanding of the molecular biology of vectors provides new insights into insect-host interactions and insect control approaches, which are key methods to prevent disease incidence in endemic areas. In this work, we describe the miRNome profiles from gut, hemolymph, and salivary gland tissues of the Rhodnius prolixus triatomine. Small RNA sequencing data revealed abundant expression of miRNAs, along with tRNA- and rRNA-derived fragments. Fifty-two mature miRNAs, previously reported in Ecdysozoa, were identified, including 39 ubiquitously expressed in the three tissues. Additionally, 112, 73, and 78 novel miRNAs were predicted in the gut, hemolymph, and salivary glands, respectively. In silico prediction showed that the top eight most highly expressed miRNAs from salivary glands potentially target human blood-expressed genes, suggesting that R. prolixus may modulate the host’s gene expression at the bite site. This study provides the first characterization of miRNAs in a Triatominae species, shedding light on the role of these crucial regulatory molecules. | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | Federal Institute of Goiás, Formosa, Brazil | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry | pt_BR |
| dc.contributor.affiliation | Muséum National d’Histoire Naturelle, UMR 7245 Molécules de Communication et Adaptation des Micro-organismes | pt_BR |
| dc.contributor.affiliation | Muséum National d’Histoire Naturelle, UMR 7245 Molécules de Communication et Adaptation des Micro-organismes | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Scientific Illustration Center | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | University of Brasília, Institute of Biology, Department of Cell Biology, Pathogen-Host Interface Laboratory | pt_BR |
| dc.contributor.affiliation | Faculty of Ceilândia, University of Brasília | pt_BR |
| dc.description.unidade | Instituto de Ciências Biológicas (IB) | pt_BR |
| dc.description.unidade | Departamento de Biologia Celular (IB CEL) | pt_BR |
| dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências Médicas | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
