Título :	Dental pulp and apical papilla cells senescence : causes, consequences, and prevention
Autor :	Farias, Jade Ormondes de Rezende, Taia Maria Berto
metadata.dc.identifier.orcid:	https://orcid.org/0000-0001-9347-3330 https://orcid.org/0000-0002-4148-0659
metadata.dc.contributor.affiliation:	Universidade de Brasília, Faculdade de Ciências de Saúde, Pós-graduação em Ciências da Saúde Universidade de Brasília, Faculdade de Ciências de Saúde, Pós-graduação em Ciências da Saúde Universidade Católica de Brasília, Curso de Odontologia Universidade Católica de Brasília, Pós-graduação em Ciências Genômicas e Biotecnologia
Assunto::	Senescência celular Polpa dentária Papila apical
Fecha de publicación :	2023
Editorial :	Springer Nature B.V
Citación :	FARIAS, Jade Ormondes de; REZENDE, Taia Maria Berto. Dental pulp and apical papilla cells senescence: causes, consequences, and prevention. Biogerontology, [S. l.], v. 24, p. 533–539, 2023. DOI: https://doi.org/10.1007/s10522-023-10029-y.
Abstract:	Dental pulp under physiological condi tions has a defense function, repair capacity, and important mechanisms in pathological processes. In addition, the dental papilla is involved in important defense processes and an essential function in the pulp revascularization process. It is known that dental pulp and apical papilla undergo a natural aging process, in addition to stressful situations such as bruxism, infammation, and infections. Both aging and stressful situations can lead to cellular senescence. Some evidence indicates that the changes resulting from this cellular state can directly afect the ef ciency of cells in these tissues and afect conservative and regenerative clinical treatments. Thus, it is nec essary to understand the causes and consequences o cellular senescence in addition to the development of methods for senescence prevention. This review aims to provide an overview of possible causes and conse quences of senescence in dental pulp and stem cells from apical papilla and discusses possible methods to prevent this cellular state.
metadata.dc.description.unidade:	Faculdade de Ciências da Saúde (FS) Departamento de Odontologia (FS ODT)
metadata.dc.description.ppg:	Programa de Pós-Graduação em Ciências da Saúde
DOI:	https://doi.org/10.1007/s10522-023-10029-y
metadata.dc.relation.publisherversion:	https://link.springer.com/article/10.1007/s10522-023-10029-y
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