Título:	Multi-level toxicity assessment of the antidepressant venlafaxine in embryos/ larvae and adults of zebrafish (Danio rerio)
Autor(es):	Oliveira, Ana Clara Fascineli, Maria Luiza Oliveira, Paula Martins de Gelfuso, Guilherme Martins Villacis, Rolando André Rios Grisolia, Cesar Koppe
ORCID:	https://orcid.org/0000-0003-3851-2696 https://orcid.org/0000-0002-4456-1577
Afiliação do autor:	Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica Universidade Federal da Paraíba, Centro de Ciências da Saúde, Departamento de Morfologia Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Tecnologia de Medicamentos, Alimentos e Cosméticos Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Tecnologia de Medicamentos, Alimentos e Cosméticos Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica
Assunto:	Peixe-zebra Venlafaxina Biomarcadores Genotoxicidade
Data de publicação:	2023
Editora:	Sociedade Brasileira de Genética
Referência:	OLIVEIRA, Ana Clara et al. Multi-level toxicity assessment of the antidepressant venlafaxine in embryos/larvae and adults of zebrafish (Danio rerio). Genetics and Molecular Biology, [S. l.], v. 46, n. 3, e20220377, 2023. DOI: https://doi.org/10.1590/1678-4685-GMB-2022-0377. Disponível em: https://www.scielo.br/j/gmb/a/TSzv9fCVKwXWQyPFPyqMndM/?lang=en. Acesso em: 07 jun. 2024.
Abstract:	The toxic effects of venlafaxine (VLX) on aquatic organisms have already been verified and therefore are a proven matter of concern. Herein, we evaluated zebrafish embryos/adults after acute exposure to VLX. Embryos/larvae were exposed to different concentrations of VLX (100-1000 mg/L; 1.33 as a dilution factor), to evaluate mortality/ developmental changes and to analyze biomarkers (0.002-100 mg/L). For adults, mortality, genotoxicity, and biomarkers were assessed in five different concentrations of VLX (1-100 mg/L). The median lethal concentration (LC50-168h) was 274.1 mg/L for embryos/larvae, and >100 mg/L for adults (LC50-96h). VLX decreased the heart rate frequency and caused premature hatching and lack of equilibrium in embryos/larvae exposed to different concentrations ranging from 100 to 562.5 mg/L. The activity of acetylcholinesterase (AChE) was inhibited in larvae exposed to 1, 25 and 100 mg/L. Glutathione-S-transferase (GST) activity was reduced in both larvae and adults after exposure to different concentrations, mainly at 25 mg/L. For both larvae and adults, lactate dehydrogenase (LDH) activity increased after 100 mg/L of VLX exposure. No DNA damage was observed in peripheral erythrocytes. Exposure to VLX may cause adverse effects on zebrafish in their early and adult life stages, interfering with embryo-larval development, and can induce physiological disturbances in adults.
Unidade Acadêmica:	Instituto de Ciências Biológicas (IB) Departamento de Genética e Morfologia (IB GEM)
Licença:	License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited
DOI:	https://doi.org/10.1590/1678-4685-GMB-2022-0377
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