| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Oliveira, Ana Clara | - |
| dc.contributor.author | Fascineli, Maria Luiza | - |
| dc.contributor.author | Oliveira, Paula Martins de | - |
| dc.contributor.author | Gelfuso, Guilherme Martins | - |
| dc.contributor.author | Villacis, Rolando André Rios | - |
| dc.contributor.author | Grisolia, Cesar Koppe | - |
| dc.date.accessioned | 2024-06-07T11:34:28Z | - |
| dc.date.available | 2024-06-07T11:34:28Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.citation | OLIVEIRA, Ana Clara et al. Multi-level toxicity assessment of the antidepressant venlafaxine in embryos/larvae and adults of zebrafish (Danio rerio). Genetics and Molecular Biology, [S. l.], v. 46, n. 3, e20220377, 2023. DOI: https://doi.org/10.1590/1678-4685-GMB-2022-0377. Disponível em: https://www.scielo.br/j/gmb/a/TSzv9fCVKwXWQyPFPyqMndM/?lang=en. Acesso em: 07 jun. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/48170 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Sociedade Brasileira de Genética | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Multi-level toxicity assessment of the antidepressant venlafaxine in embryos/ larvae and adults of zebrafish (Danio rerio) | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Peixe-zebra | pt_BR |
| dc.subject.keyword | Venlafaxina | pt_BR |
| dc.subject.keyword | Biomarcadores | pt_BR |
| dc.subject.keyword | Genotoxicidade | pt_BR |
| dc.rights.license | License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited | pt_BR |
| dc.identifier.doi | https://doi.org/10.1590/1678-4685-GMB-2022-0377 | pt_BR |
| dc.description.abstract1 | The toxic effects of venlafaxine (VLX) on aquatic organisms have already been verified and therefore are a proven
matter of concern. Herein, we evaluated zebrafish embryos/adults after acute exposure to VLX. Embryos/larvae
were exposed to different concentrations of VLX (100-1000 mg/L; 1.33 as a dilution factor), to evaluate mortality/
developmental changes and to analyze biomarkers (0.002-100 mg/L). For adults, mortality, genotoxicity, and biomarkers
were assessed in five different concentrations of VLX (1-100 mg/L). The median lethal concentration (LC50-168h) was
274.1 mg/L for embryos/larvae, and >100 mg/L for adults (LC50-96h). VLX decreased the heart rate frequency and
caused premature hatching and lack of equilibrium in embryos/larvae exposed to different concentrations ranging
from 100 to 562.5 mg/L. The activity of acetylcholinesterase (AChE) was inhibited in larvae exposed to 1, 25 and
100 mg/L. Glutathione-S-transferase (GST) activity was reduced in both larvae and adults after exposure to different
concentrations, mainly at 25 mg/L. For both larvae and adults, lactate dehydrogenase (LDH) activity increased after
100 mg/L of VLX exposure. No DNA damage was observed in peripheral erythrocytes. Exposure to VLX may cause
adverse effects on zebrafish in their early and adult life stages, interfering with embryo-larval development, and can
induce physiological disturbances in adults. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-3851-2696 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4456-1577 | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica | pt_BR |
| dc.contributor.affiliation | Universidade Federal da Paraíba, Centro de Ciências da Saúde, Departamento de Morfologia | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Tecnologia de Medicamentos, Alimentos e Cosméticos | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Tecnologia de Medicamentos, Alimentos e Cosméticos | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Laboratório de Genética Toxicológica | pt_BR |
| dc.description.unidade | Instituto de Ciências Biológicas (IB) | pt_BR |
| dc.description.unidade | Departamento de Genética e Morfologia (IB GEM) | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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