Título:	In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
Autor(es):	Pires, Felipe Queiroz Gross, Idejan Padilha Barreto, Livia Cristina Lira de Sá Gratieri, Taís Gelfuso, Guilherme Martins Báo, Sônia Nair Cunha Filho, Marcílio Sérgio Soares da
Afiliação do autor:	University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Faculty of Ceilandia University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Institute of Biological Sciences, Laboratório de Microscopia e Microanálise University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics
Assunto:	Naringenina Nanopartículas Medicamentos
Data de publicação:	3-Jul-2023
Editora:	Elsevier B.V.
Referência:	PIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024.
Abstract:	The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more popular due to the dizzying advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect oral drug bioavailability and needs to be monitored.
Unidade Acadêmica:	Faculdade UnB Ceilândia (FCE) Curso de Farmácia (FCE-FAR) Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR) Instituto de Ciências Biológicas (IB) Departamento de Biologia Celular (IB CEL)
Licença:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
DOI:	https://doi.org/10.1016/j.ejps.2023.106517
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