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Título: BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil
Autor(es): Duarte, Ligia C. A. Cardoso
Fratelli, Caroline Ferreira
Pereira, Alexandre Sampaio Rodrigues
Souza, Jéssica Nayane Gomes de
Freitas, Renata de Souza
Morais, Rafael Martins de
Barra Sobrinho, Alaor
Silva, Calliandra Maria de Souza
Oliveira, Jamila Reis de
Oliveira, Diêgo Madureira de
Silva, Izabel Cristina Rodrigues da
ORCID: https://orcid.org/0000-0002-9335-999X
https://orcid.org/0000-0002-0511-9452
https://orcid.org/0000-0002-9064-0735
https://orcid.org/0000-0002-9577-0344
https://orcid.org/0000-0002-6836-3583
Afiliação do autor: Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Centro Universitário do Distrito Federal
Hospital Sírio-Libanês, Brasília
Imagens Médicas de Brasília (IMEB)
Universidade de Brasília
Universidade de Brasília
Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde
Assunto: Polimorfismo genético
Tireóide - câncer
Data de publicação: 2021
Editora: Sage
Referência: DUARTE, Ligia C. A. Cardoso et al. BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil. The International Journal of Biological Markers, v. 36, n. 4, 2021. DOI: https://doi.org/10.1177/17246008211057576. Disponível em: https://journals.sagepub.com/doi/full/10.1177/17246008211057576. Acesso em: 11 out. 2023.
Resumo: Introduction: Papillary thyroid cancer corresponds to approximately 1% of all carcinomas; nevertheless, it is the most prevalent endocrine neoplasm in the world. Studies reveal that the BAX (−248 G > A) polymorphism may be associated with negative regulation of BAX gene transcription activity, causing a decrease in its protein expression. Objective: The present study aimed to describe the genotype and allele frequencies of BAX single nucleotide polymorphisms (−248 G > A) (rs4645878) in the research patients, and to associate its presence with susceptibility to papillary thyroid cancer. Methods: This case-control study was conducted with 30 patients with papillary thyroid cancer. For the evaluation of genetic polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism technique was employed. Allele and genotype frequencies were estimated using the SPSS program, and significant associations were considered when p < 0.05. Results: There was a significant genotypic difference between papillary thyroid cancer and the control group (p = 0.042). The GG genotype provided a protective factor for papillary thyroid cancer (p = 0.012, odds ratio (OR) = 0.313; confidence inter- val (CI) = 0.123–0.794). Likewise the G allele was a protective factor for papillary thyroid cancer (p = 0.009; OR = 0.360; CI = 0.163–0.793). The BAX gene polymorphism (−248 G > A) was associated with papillary thyroid cancer. Conclusion: BAX (−248 G > A) GG genotype carriers, or at least one mutated allele, was associated with papillary thyroid cancer in the Brazilian population studied, and the G allele presence is considered a protective factor against papillary thyroid cancer occurrence.
Unidade Acadêmica: Faculdade UnB Ceilândia (FCE)
Programa de pós-graduação: Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Licença: Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
DOI: https://doi.org/10.1177/17246008211057576
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