DC Field | Value | Language |
dc.contributor.author | Duarte, Ligia C. A. Cardoso | - |
dc.contributor.author | Fratelli, Caroline Ferreira | - |
dc.contributor.author | Pereira, Alexandre Sampaio Rodrigues | - |
dc.contributor.author | Souza, Jéssica Nayane Gomes de | - |
dc.contributor.author | Freitas, Renata de Souza | - |
dc.contributor.author | Morais, Rafael Martins de | - |
dc.contributor.author | Barra Sobrinho, Alaor | - |
dc.contributor.author | Silva, Calliandra Maria de Souza | - |
dc.contributor.author | Oliveira, Jamila Reis de | - |
dc.contributor.author | Oliveira, Diêgo Madureira de | - |
dc.contributor.author | Silva, Izabel Cristina Rodrigues da | - |
dc.date.accessioned | 2023-10-11T15:20:45Z | - |
dc.date.available | 2023-10-11T15:20:45Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | DUARTE, Ligia C. A. Cardoso et al. BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil. The International Journal of Biological Markers, v. 36, n. 4, 2021. DOI: https://doi.org/10.1177/17246008211057576. Disponível em: https://journals.sagepub.com/doi/full/10.1177/17246008211057576. Acesso em: 11 out. 2023. | pt_BR |
dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/46665 | - |
dc.description.abstract | Introduction: Papillary thyroid cancer corresponds to approximately 1% of all carcinomas; nevertheless, it is the most
prevalent endocrine neoplasm in the world. Studies reveal that the BAX (−248 G > A) polymorphism may be associated
with negative regulation of BAX gene transcription activity, causing a decrease in its protein expression.
Objective: The present study aimed to describe the genotype and allele frequencies of BAX single nucleotide polymorphisms
(−248 G > A) (rs4645878) in the research patients, and to associate its presence with susceptibility to papillary thyroid cancer.
Methods: This case-control study was conducted with 30 patients with papillary thyroid cancer. For the evaluation of genetic
polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism technique was employed. Allele and
genotype frequencies were estimated using the SPSS program, and significant associations were considered when p < 0.05.
Results: There was a significant genotypic difference between papillary thyroid cancer and the control group (p = 0.042). The
GG genotype provided a protective factor for papillary thyroid cancer (p = 0.012, odds ratio (OR) = 0.313; confidence inter-
val (CI) = 0.123–0.794). Likewise the G allele was a protective factor for papillary thyroid cancer (p = 0.009; OR = 0.360; CI =
0.163–0.793). The BAX gene polymorphism (−248 G > A) was associated with papillary thyroid cancer.
Conclusion: BAX (−248 G > A) GG genotype carriers, or at least one mutated allele, was associated with papillary thyroid
cancer in the Brazilian population studied, and the G allele presence is considered a protective factor against papillary thyroid
cancer occurrence. | pt_BR |
dc.language.iso | por | pt_BR |
dc.publisher | Sage | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.title | BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil | pt_BR |
dc.type | Artigo | pt_BR |
dc.subject.keyword | Polimorfismo (Genética) | pt_BR |
dc.subject.keyword | Tireóide - câncer | pt_BR |
dc.rights.license | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). | pt_BR |
dc.identifier.doi | https://doi.org/10.1177/17246008211057576 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-9335-999X | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-0511-9452 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-9064-0735 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-9577-0344 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-6836-3583 | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.contributor.affiliation | Centro Universitário do Distrito Federal | pt_BR |
dc.contributor.affiliation | Hospital Sírio-Libanês, Brasília | pt_BR |
dc.contributor.affiliation | Imagens Médicas de Brasília (IMEB) | pt_BR |
dc.contributor.affiliation | Universidade de Brasília | pt_BR |
dc.contributor.affiliation | Universidade de Brasília | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.contributor.affiliation | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde | pt_BR |
dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
dc.description.ppg | Programa de Pós-Graduação em Ciências e Tecnologias em Saúde | pt_BR |
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