Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles

Nunes, Ricardo Ferreira; Cunha Filho, Marcílio Sérgio Soares da; Gratieri, Taís; Gelfuso, Guilherme Martins

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Campo DC	Valor	Idioma
dc.contributor.author	Nunes, Ricardo Ferreira	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.date.accessioned	2021-11-10T15:21:38Z	-
dc.date.available	2021-11-10T15:21:38Z	-
dc.date.issued	2021	-
dc.identifier.citation	NUNES, Ricardo Ferreira et al. Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles. Colloids and Surfaces B: Biointerfaces, v. 208, 112101, 2021. DOI: https://doi.org/10.1016/j.colsurfb.2021.112101.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/42350	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier B.V.	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Acne	pt_BR
dc.subject.keyword	Alopecia	pt_BR
dc.subject.keyword	Folículo capilar	pt_BR
dc.subject.keyword	Copolímero de ácido metacrílico / metacrilato de metila	pt_BR
dc.subject.keyword	Poli-ε-caprolactona	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.colsurfb.2021.112101	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/abs/pii/S0927776521005452?via%3Dihub	pt_BR
dc.description.abstract1	This study proposes developing a topical formulation based on poly-ε-caprolactone (PCL) or methacrylic acid/methyl methacrylate copolymer (EL100) nanoparticles to enable a safer and more effective therapy of alopecia and acne with spironolactone. The effect of the size of the nanoparticle on follicular-targeted drug delivery is also verified. Compatibility studies based on thermal analyses and complementary techniques showed a small interaction of the drug with excipients, which may not compromise the drug stability. PCL nanoparticles of 180.0 ± 1.6 and 126.8 ± 1.0 nm, and EL100 nanoparticles of 102.7 ± 7.1 nm were then prepared. All nanoparticles entrapped more than 75 % of spironolactone, were physically stable, and stabilized the drug for at least 90 days. They were also non-irritant according to HET-CAM tests. Drug release from the nanoparticles was reduced in aqueous buffer media but fast when in contact with oil. Finally, in vitro skin penetration experiments revealed the largest nanoparticles (of 180 nm) targeted drug delivery to the hair follicles 5-fold (p < 0.05) more than the control solution, 2.1-fold (p < 0.05) more than nanoparticles produced with the same polymer (PCL) but with smaller size (123 nm), and 4.9-fold (p < 0.05) more than the 102-nm E100 nanoparticles. In conclusion, follicular targeting can be adjusted according to nanoparticle size, and this work succeeded in obtaining polymeric nanoparticles adequate to enable topical treatment of acne and alopecia with spironolactone.	pt_BR
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