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Universidade de Brasília
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dc.contributor.authorTeixeira Júnior, Antonio Augusto Lima-
dc.contributor.authorNeves, Precil Diego Miranda de Menezes-
dc.contributor.authorLages, Joyce Santos-
dc.contributor.authorCunha, Kaile de Araújo-
dc.contributor.authorMuniz, Monique Pereira Rêgo-
dc.contributor.authorBrito, Dyego José de Araújo-
dc.contributor.authorWatanabe, Andréia-
dc.contributor.authorWatanabe, Elieser Hitoshi-
dc.contributor.authorOnuchic, Luiz Fernando-
dc.contributor.authorNunes, Lucas Lobato Acatauassu-
dc.contributor.authorCoutinho Filho, Antônio Fernando-
dc.contributor.authorBarcelos, Flávia Lara-
dc.contributor.authorGatto, Giuseppe Cesare-
dc.contributor.authorMonteiro, Antonio-
dc.contributor.authorPolido, Diego do Amaral-
dc.contributor.authorMotta, Douglas Rafanelle Moura de Santana-
dc.contributor.authorLeite, Thaísa de Oliveira-
dc.contributor.authorGuedes, Felipe Leite-
dc.contributor.authorGomes, Orlando Vieira-
dc.contributor.authorValente, Lucila Maria-
dc.contributor.authorIsrael, Karla Cristina Silva Petruccelli-
dc.contributor.authorLadchumananandasivam, Francisco Rasiah-
dc.contributor.authorFarias, Lígia Cristina Lopes de-
dc.contributor.authorMarques, Igor Denizarde Bacelar-
dc.contributor.authorUliano, Gustavo Lemos-
dc.contributor.authorMaramaldo, Carlos Eduardo Campos-
dc.contributor.authorLima Neto, Lídio Gonçalves-
dc.contributor.authorLuchi, Weverton Machado-
dc.contributor.authorWanderley, David Campos-
dc.contributor.authorAraújo, Stanley de Almeida-
dc.contributor.authorSalgado Filho, Natalino-
dc.contributor.authorSilva, Gyl Eanes Barros-
dc.date.accessioned2020-12-31T16:00:17Z-
dc.date.available2020-12-31T16:00:17Z-
dc.date.issued2020-10-23-
dc.identifier.citationTEIXEIRA JÚNIOR, Antonio Augusto Lima et al. Brazilian consortium for the study on renal diseases associated with COVID-19: a multicentric effort to understand SARS-CoV-2-related nephropathy. Frontiers in Medicine, v. 7, art. 584235, out. 2020. DOI: https://doi.org/10.3389/fmed.2020.584235. Disponível em: https://www.frontiersin.org/articles/10.3389/fmed.2020.584235/full. Acesso em: 31 dez. 2020.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/39843-
dc.language.isoInglêspt_BR
dc.publisherFrontierspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleBrazilian consortium for the study on renal diseases associated with COVID-19 : a multicentric effort to understand SARS-CoV-2-related nephropathypt_BR
dc.typeArtigopt_BR
dc.subject.keywordCovid-19pt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordGlomerulopatiaspt_BR
dc.subject.keywordRins - doençaspt_BR
dc.subject.keywordMicroangiopatia trombóticapt_BR
dc.rights.licenseCopyright © 2020 Teixeira Júnior, Neves, Lages, Cunha, Muniz, Brito, Watanabe, Watanabe, Onuchic, Nunes, Coutinho Filho, Barcelos, Gatto, Monteiro, Polido, Motta, Leite, Guedes, Gomes, Valente, Israel, Ladchumananandasivam, de Farias, Marques, Uliano, Maramaldo, Neto, Luchi, Wanderley, Araújo, Salgado Filho and Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_BR
dc.identifier.doihttps://doi.org/10.3389/fmed.2020.584235pt_BR
dc.description.abstract1Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Serviços Hospitalares (EBSERH) network, as well as some state hospitals and an autopsy center. All biopsies will be sent to the referral center for renal pathology of the EBSERH network. The data will include patients who had coronavirus disease, both alive and deceased, with or without pre-existing kidney disease. Kidney biopsies will be analyzed by light, fluorescence, and electron microscopy. Furthermore, immunohistochemical (IHC) staining for various inflammatory cells (i.e., cells expressing CD3, CD20, CD4, CD8, CD138, CD68, and CD57) as well as angiotensin-converting enzyme 2 (ACE2) will be performed on paraffinized tissue sections. In addition to ultrastructural assays, in situ hybridization (ISH), IHC and reverse transcription-polymerase chain reaction (RT-PCR) will be used to detect Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in renal tissue. For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping. For patients with thrombotic microangiopathy, thrombospondin type 1 motif, member 13 (ADAMTS13), antiphospholipid, and complement panel will be performed. The setting of this study is Brazil, which is second behind the United States in highest confirmed cases and deaths. With this complete approach, we hope to help define the spectrum and impact, whether immediate or long-term, of kidney injury caused by SARS-CoV-2.pt_BR
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