Título :	A mild, fast, and scalable synthesis of substituted a-acyloxy ketones via multicomponent reaction using a continuous flow approach
Autor :	Salvador, Carlos Eduardo de Melo Andrade, Carlos Kleber Zago de
Assunto::	Cetonas Reações químicas Microondas
Fecha de publicación :	30-jul-2019
Editorial :	Frontiers
Citación :	SALVADOR, Carlos Eduardo M.; ANDRADE, Carlos Kleber Z. A mild, fast, and scalable synthesis of substituted a-acyloxy ketones via multicomponent reaction using a continuous flow approach. Frontiers in Chemistry, v. 7, art. 531, jul. 2019. DOI: https://doi.org/10.3389/fchem.2019.00531. Disponível em: https://www.frontiersin.org/articles/10.3389/fchem.2019.00531/full. Acesso em: 12 nov. 2019.
Abstract:	A continuous flow approach for the synthesis of a-acyloxy ketone derivatives from the corresponding arylglyoxals, isocyanides, and carboxylic acids is described. The target products were obtained in excellent yields in short residence times and with high purities via the first transcription of the microwave-to-flow paradigm to the isocyanide-based Passerini reaction. Furthermore, this methodology allowed a 10-fold scale-up using the same experimental conditions initially established.
metadata.dc.description.unidade:	Instituto de Química (IQ)
Licença::	Copyright © 2019 Salvador and Andrade. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fchem.2019.00531
Aparece en las colecciones:	Artigos publicados em periódicos e afins

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