Title:	Bioinformatics of the Paracoccidioides brasiliensis EST Project
Authors:	Brígido, Marcelo de Macedo Walter, Maria Emília Machado Telles Oliveira, Adilton G. Inoue, Marcus K. Anjos, Daniel dos Santos Sandes, Edans Flávius de Oliveira Gondim, João José da Costa Carvalho, Maria José de Albuquerque Almeida Júnior, Nalvo Franco de Felipe, Maria Sueli Soares
Assunto::	Biologia computacional Paracoccidioides brasiliensis
Issue Date:	2005
Publisher:	FUNPEC-RP
Citation:	BRÍGIDO, Marcelo de Macedo et al. Bioinformatics of the Paracoccidioides brasiliensis EST Project. Genetics and Molecular Research, v. 4, n.2, p. 203-215, 2005. Disponível em: <http://www.funpecrp.com.br/gmr/year2005/vol2-4/pdf/Pb01.pdf>. Acesso em: 15 jun. 2018.
Abstract:	Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, an endemic mycosis of Latin America. This fungus presents a dimorphic character; it grows as a mycelium at room temperature, but it is isolated as yeast from infected individuals. It is believed that the transition from mycelium to yeast is important for the infective process. The Functional and Differential Genome of Paracoccidioides brasiliensis Project - PbGenome Project was developed to study the infection process by analyzing expressed sequence tags - ESTs, isolated from both mycelial and yeast forms. The PbGenome Project was executed by a consortium that included 70 researchers (professors and students) from two sequencing laboratories of the midwest region of Brazil; this project produced 25,741 ESTs, 19,718 of which with sufficient quality to be analyzed. We describe the computational procedures used to receive process, analyze these ESTs, and help with their functional annotations; we also detail the services that were used for sequence data exploration. Various programs were compared for filtering and grouping the sequences, and they were adapted to a user-friendly interface. This system made the analysis of the differential transcriptome of P. brasiliensis possible.
Licença::	Genetics and Molecular Research - Autorização concedida ao Repositório Institucional da Universidade de Brasília (RIUnB) pelo editor da revista, em 29 mar. 2016, com os seguintes termos: disponível sob Licença Creative Commons 4.0 International, que permite copiar, distribuir e transmitir o trabalho, desde que seja citado o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação desta.
Appears in Collections:	Artigos publicados em periódicos e afins UnB - Professores Eméritos

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