Title:	Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital : a descriptive study
Authors:	Freitas, Felipe Teixeira de Mello Romero, Gustavo Adolfo Sierra
Assunto::	Sepse Maternidade - Brasil
Issue Date:	Feb-2017
Publisher:	Brazilian Society of Infectious Diseases
Citation:	FREITAS, Felipe Teixeira de Mello; ROMERO, Gustavo Adolfo Sierra. Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study. Brazilian Journal of Infectious Diseases, Salvador, v. 21, n. 1, p. 92-97, jan./fev. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100092&lng=en&nrm=iso>. Acesso em: 25 jan. 2018. doi: http://dx.doi.org/10.1016/j.bjid.2016.09.013.
Abstract:	Objectives: to describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil. Methods: we defined EOS as a positive blood culture result obtained from infants aged ≤72 hours of life plus treatment with antibiotic therapy for ≥5 days. Incidence was calculated based on the number of cases and total live births (LB). This is a descriptive study comparing the period of 2012–2013 with the period of 2014–September 2015, before and after implementation of antibiotic prophylaxis during labor for group B streptococcus (GBS) prevention, respectively. Results: overall, 36 infants developed EOS among 21,219 LB (1.7 cases per 1000 LB) and 16 died (case fatality rate of 44%). From 2014, 305 vaginal-rectal swabs were collected from high-risk women and 74 (24%) turned out positive for GBS. After implementation of GBS prevention guidelines, no new cases of GBS were detected, and the EOS incidence was reduced from 1.9 (95% CI 1.3–2.8) to 1.3 (95% CI 0.7–2.3) cases per 1000 LB from 2012–2013 to 2014–September 2015 (p = 0.32). Conclusions: although the reduction of EOS incidence was not significant, GBS colonization among pregnant women was high, no cases of neonatal GBS have occurred after implementation of prevention guidelines.
metadata.dc.description.unidade:	Faculdade de Medicina (FMD)
Licença::	Brazilian Journal of Infectious Diseases - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100092&lng=en&nrm=iso. Acesso em: 25 jan. 2018.
DOI:	http://dx.doi.org/10.1016/j.bjid.2016.09.013
Appears in Collections:	Artigos publicados em periódicos e afins

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