Title:	Expression of CD90 and P75NTR stem cell markers in ameloblastomas : a possible role in their biological behavior
Authors:	Silva, Fernanda Paula Yamamoto Dias, Andrielle Coelho, Carolinne Almeida Guerra, Eliete Neves Marques, Ana Elizia Mascarenhas Decurcio, Daniel de Almeida Mantesso, Andrea Cury, Sérgio Elias Vieira Silva, Brunno Santos de Freitas
Assunto::	Células-tronco Antígenos Ameloblastoma
Issue Date:	2016
Publisher:	Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Citation:	SILVA, Fernanda Paula Yamamoto et al. Expression of CD90 and P75NTR stem cell markers in ameloblastomas: a possible role in their biological behavior. Brazilian Oral Research, São Paulo, v. 30, n. 1, e109, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100298&lng=en&nrm=iso>. Acesso em: 18 dez. 2017. Epub Oct 10, 2016. doi: http://dx.doi.org/10.1590/1807-3107BOR-2016.vol30.0109.
Abstract:	Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively. The Kolmogorov-Smirnov test was used to verify possible differences in CD90 and P75NTR expressions between multicystic and unicystic ameloblastomas (p < 0.05). CD90 immunostaining was observed in all multicystic ameloblastoma specimens (n = 10), in the cytoplasm of the fibroblasts and vascular endothelial cells of the tumor stroma, near the neoplastic odontogenic epithelia. The staining of stromal CD90 was significantly higher in multicystic than in unicystic ameloblastomas (p = 0.003). Nuclear P75NTR immunostaining was observed in all ameloblastoma specimens. A significant difference was seen in the epithelial staining of P75NTR between multicystic and unicystic types (p = 0.007). The increased expression of CD90 and P75NTR found in multicystic ameloblastomas suggests a behavioral biological difference between multicystic and unicystic ameloblastomas, as well as a difference in ameloblastoma development.
Licença::	Brazilian Oral Research - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242016000100298&lng=en&nrm=iso. Acesso em: 18 dez. 2017.
DOI:	http://dx.doi.org/10.1590/1807-3107BOR-2016.vol30.0109
Appears in Collections:	Artigos publicados em periódicos e afins

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