Título:	Does acute alcohol intoxication interfere with colonic anastomosis wound healing? : a rat model of nondestructive colon trauma
Autor(es):	Morais, Pedro Henrique Alves de Farias, Igor Eduardo Caetano de Ribeiro, Vinícius Lacerda Silva, Luiz Eduardo Almeida Carneiro, Fabiana Pirani Veiga, Joel Paulo Russomano Sousa, João Batista de
Assunto:	Cicatrização de feridas Alcoolismo Etanol Ratos
Data de publicação:	2013
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	MORAIS, Pedro Henrique Alves de et al. Does acute alcohol intoxication interfere with colonic anastomosis wound healing?: a rat model of nondestructive colon trauma. Acta Cirúrgica Brasileira, v. 28, n. 10, p. 703-707, 2013. DOI: https://doi.org/10.1590/S0102-86502013001000003. Disponível em: https://www.scielo.br/j/acb/a/cfvmTgXqffGZDFbYFMgqbLJ/?lang=en#. Acesso em: 10 jul. 2021.
Abstract:	PURPOSE: To evaluate the effects of acute alcohol intoxication on healing of colonic anastomosis. METHODS: Thirty-six rats were allocated into two groups. Animals in the alcohol (A) were given 2 mL of ethanol diluted in 0.9% saline solution to a concentration of 40% by gavage immediately before anesthesia, whereas control (C) animals received 2 mL of 0.9% saline solution via the same route. A colonic anastomosis was then performed in all animals. On postoperative days 1, 3, and 7, anastomotic breaking strength was assessed and histopathological examination was performed. Change in body weight and mortality were also evaluated. RESULTS: The median of anastomotic tensile strength on the postoperative day 1 was 0.09 Newtons for group A and 0.13 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 3 was 0.13 Newtons for group A and 0.17 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 7 was 0.30 Newtons for group A and 0.35 for group C. (p>0.05). There was no significant difference between the groups A and C, in the first, third or seventh POD (p>0.05), in any of the analyzed parameters. There were no statistical differences between groups in the weight. Three animals died, all from the group A. CONCLUSION: Acute alcohol intoxication did not interfere with wound healing of colonic anastomoses, although it caused early postoperative mortality.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Acta Cirúrgica Brasileira - This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC). Fonte: https://www.scielo.br/j/acb/a/cfvmTgXqffGZDFbYFMgqbLJ/?lang=en#. Acesso em: 10 jul. 2021.
DOI:	https://dx.doi.org/10.1590/S0102-86502013001000003
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