Título:	Evolution and pathology in Chagas disease : a review
Autor(es):	Teixeira, Antonio Raimundo Lima Cruz Nascimento, Rubens J. Sturm, Nancy R.
Assunto:	Tripanossoma cruzi DNA de cinetoplasto Transferência horizontal Genoma Mutação de kDNA Patologia
Data de publicação:	2006
Editora:	Instituto Oswaldo Cruz, Ministério da Saúde
Referência:	TEIXEIRA, Antonio RL; NASCIMENTO, Rubens J; STURM, Nancy R. Evolution and pathology in Chagas disease: a review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 5, p. 463-491, ago. 2006. DOI: http://dx.doi.org/10.1590/S0074-02762006000500001. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500001&lng=en&nrm=iso. Acesso em: 01 fev. 2019.
Abstract:	Trypanosoma cruzi acute infections often go unperceived, but one third of chronically infected individuals die of Chagas disease, showing diverse manifestations affecting the heart, intestines, and nervous systems. A common denominator of pathology in Chagas disease is the minimal rejection unit, whereby parasite-free target host cells are destroyed by immune system mononuclear effectors cells infiltrates. Another key feature stemming from T. cruzi infection is the integration of kDNA minicircles into the vertebrate host genome; horizontal transfer of the parasite DNA can undergo vertical transmission to the progeny of mammals and birds. kDNA integration-induced mutations can enter multiple loci in diverse chromosomes, generating new genes, pseudo genes and knock-outs, and resulting in genomic shuffling and remodeling over time. As a result of the juxtaposition of kDNA insertions with host open reading frames, novel chimeric products may be generated. Germ line transmission of kDNA-mutations determined the appearance of lesions in birds that are indistinguishable from those seen in Chagas disease patients. The production of tissue lesions showing typical minimal rejection units in birds' refractory to T. cruzi infection is consistent with the hypothesis that autoimmunity, likely triggered by integration-induced phenotypic alterations, plays a major role in the pathogenesis of Chagas disease.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Memórias do Instituto Oswaldo Cruz - (CC BY NC) -  All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500001. Acesso em: 01 fev. 2019.
DOI:	http://dx.doi.org/10.1590/S0074-02762006000500001
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