Title:	Action of pentoxifylline on experimental cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis
Authors:	Oliveira, Thiago de Sá Capp Neto, Mário Martins, Bernardo José Alves Rodrigues, Helbert Abe Antonino, Rosa Maria Parreiras Magalhães, Albino Verçosa de
Assunto::	Leishmaniose cutânea Leishmaniose Fator de necrose de tumor
Issue Date:	Aug-2000
Publisher:	Instituto Oswaldo Cruz, Ministério da Saúde
Citation:	OLIVEIRA, Thiago de Sá et al. Action of pentoxifylline on experimental cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 4, p. 477-482, jul./ago. 2000. DOI: https://doi.org/10.1590/S0074-02762000000400006. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000400006&lng=en&nrm=iso. Acesso: 19 mar. 2021.
Abstract:	In the animal model of leishmaniasis caused by Leishmania (Leishmania) amazonensis there is a complex mechanism of the host-parasite interaction. The present study was performed to interfere with the inflammatory reaction to the parasites, through immune modulation. Female C5BL/6 isogenic mice were used, some of which were inoculated on the right ear and others on the right footpad with 3.10(6) stationary phase promastigotes of the MHOM/BR/PH8 strain of L. (L.) amazonensis, and were allocated in three groups: the first received pentoxifylline 8mg/kg every 12 h, since the first day; the second one received the same dose since the 40th day of infection and a control group that did not receive any treatment. All the ears excised were analyzed to determine the variation in weight between both ears and for histopathological analyses. A quantification of the parasites was done using the limiting dilution assay. A significant reduction of the number of parasites, was observed among the animals treated which had an accordingly significant reduction on the weight of the ears. Pentoxifylline reduced the macrophages propensity to vacuolation and induced a more effective destruction of the parasites by these cells. Moreover, the group that began the treatment later did not show the same effectiveness.
metadata.dc.description.unidade:	Faculdade de Medicina (FM)
Licença::	Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000400006&lng=en&tlng=en. Acesso em: 19 mar. 2021.
DOI:	https://dx.doi.org/10.1590/S0074-02762000000400006
Appears in Collections:	Artigos publicados em periódicos e afins

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