Título:	Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats
Autor(es):	Petriz, Bernardo A. Castro, Alinne Pereira de Almeida, Jeeser A. Gomes, Clarissa P. C. Fernandes, Gabriel R. Kruger, Ricardo Henrique Pereira, Rinaldo Wellerson Franco, Octávio Luiz
Assunto:	Lactobacilo Exercícios Hipertensão Obesidade
Data de publicação:	2014
Editora:	BioMed Central
Referência:	PETRIZ, Bernardo A. et al. Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats. BMC Genomics, v. 15, n. 511, 2014. Disponível em: <http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-511>. Acesso em: 12 dez. 2016. DOI: 10.1186/1471-2164-15-511
Abstract:	Background: Obesity is a multifactor disease associated with cardiovascular disorders such as hypertension. Recently, gut microbiota was linked to obesity pathogenesisand shown to influence the host metabolism. Moreover, several factors such as host-genotype and life-style have been shown to modulate gut microbiota composition. Exercise is a well-known agent used for the treatment of numerous pathologies, such as obesity and hypertension; it has recently been demonstrated to shape gut microbiota consortia. Since exercise-altered microbiota could possibly improve the treatment of diseases related to dysfunctional microbiota, this study aimed to examine the effect of controlled exercise training on gut microbial composition in Obese rats (n = 3), non-obese Wistar rats (n = 3) and Spontaneously Hypertensive rats (n = 3). Pyrosequencing of 16S rRNA genes from fecal samples collected before and after exercise training was used for this purpose. Results: Exercise altered the composition and diversity of gut bacteria at genus level in all rat lineages. Allobaculum (Hypertensive rats), Pseudomonas and Lactobacillus (Obese rats) were shown to be enriched after exercise, while Streptococcus (Wistar rats), Aggregatibacter and Sutturella (Hypertensive rats) were more enhanced before exercise. A significant correlation was seen in the Clostridiaceae and Bacteroidaceae families and Oscillospira and Ruminococcus genera with blood lactate accumulation. Moreover, Wistar and Hypertensive rats were shown to share a similar microbiota composition, as opposed to Obese rats. Finally, Streptococcus alactolyticus, Bifidobacterium animalis, Ruminococcus gnavus, Aggregatibacter pneumotropica and Bifidobacterium pseudolongum were enriched in Obese rats. Conclusions: These data indicate that non-obese and hypertensive rats harbor a different gut microbiota from obese rats and that exercise training alters gut microbiota from an obese and hypertensive genotype background.
Licença:	© 2014 Petriz et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Fonte: http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-511. Acesso em: 12 dez. 2016.
DOI:	https://dx.doi.org/10.1186/1471-2164-15-511
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