http://repositorio.unb.br/handle/10482/12393
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Título : | Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells |
Autor : | Felipe, Maria Sueli Soares Andrade, Rosângela Vieira de Arraes, Fabrício Barbosa Monteiro Nicola, André Moraes Maranhão, Andréa Queiroz Torres, Fernando Araripe Gonçalves Pereira, Ildinete Silva Fonseca, Márcio José Poças Campos, Élida Geralda Moraes, Lídia Maria Pepe de Andrade, Patrícia Albuquerque de Tavares, Aldo Henrique Fonseca Pacheco Silva, Simoneide Souza Kyaw, Cynthia Maria Souza, Diorge Paulo PbGenome Network Pereira, Maristela Jesuíno, Rosália Santos Amorim Andrade, Edmar Vaz de Parente, Juliana Alves Oliveira, Gisele Silva de Barbosa, Mônica Santiago Martins, Natália Florêncio Fachin, Ana Lúcia Cardoso, Renato Sousa Passos Júnior, Geraldo Aleixo da Silva Almeida Júnior, Nalvo Franco de Walter, Maria Emília Machado Telles Soares, Célia Maria de Almeida Carvalho, Maria José Albuquerque de Brígido, Marcelo de Macedo |
Assunto:: | Paracoccidioides brasiliensis Fungos patogênicos Micologia |
Fecha de publicación : | jul-2005 |
Editorial : | Sociedade Americana de Bioquímica e Biologia Molecular |
Citación : | FELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200 |
Resumen : | Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, covering about 80% of the estimated genome of this dimorphic, thermo-regulated fungus. The data provide a comprehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in mycelium and yeast cells was detected, which was confirmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about sequences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identified, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets. |
Descripción : | This work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. Reis |
Licença:: | Permitido copiar, distribuir, transmitir e adaptar a obra - sem nenhum custo e sem permissão - para uso não comercial, desde que citada a fonte original. "This research was originally published in The Journal of Biological Chemistry. Maria Sueli S. Felipe, Rosângela V. Andrade, Fabrício B. M. Arraes, André M. Nicola, Andrea Q. Maranhão, Fernando A. G. Torres, Ildinete Silva-Pereira, Márcio J. Poças-Fonseca, Élida G. Campos,a Lídia M. P. Moraes,a Patrícia A. Andrade,Aldo H. F. P. Tavares, Simoneide S. Silva, Cynthia M. Kyaw,a Diorge P. Souza,PbGenome Network, Maristela Pereira,a Rosália S. A. Jesuíno, Edmar V. Andrade,Juliana A. Parente, Gisele S. Oliveira, Mônica S. Barbosa, Natália F. Martins, Ana L. Fachin, Renato S. Cardoso, Geraldo A. S. Passos, Nalvo F. Almeida, Maria Emília M. T. Walter,Célia M. A. Soares,Maria José A. Carvalho and Marcelo M. Brígido. Transcriptional Profiles of the Human Pathogenic Fungus Paracoccidioides brasiliensis in Mycelium and Yeast Cells. The Journal of Biological Chemistry. 2005, Vol. 280, No. 26, Issue of July 1, pp. 24706–24714. © Sociedade Americana de Bioquímica e Biologia Molecular." Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml. Acesso em: 07 mar. 2013. |
DOI: | DOI https://dx.doi.org/10.1074/jbc.M500625200 |
Aparece en las colecciones: | Artigos publicados em periódicos e afins UnB - Professores Eméritos |
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