| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Barbalho, Geisa Nascimento | pt_BR |
| dc.contributor.author | Brugger, Stefan | pt_BR |
| dc.contributor.author | Raab, Christian | pt_BR |
| dc.contributor.author | Lechner, Jara Sophie | pt_BR |
| dc.contributor.author | Gratieri, Taís | pt_BR |
| dc.contributor.author | Keck, Cornelia M. | pt_BR |
| dc.contributor.author | Rupenthal, Ilva D. | pt_BR |
| dc.contributor.author | Agarwal, Priyanka | pt_BR |
| dc.date.accessioned | 2026-06-09T22:34:58Z | - |
| dc.date.available | 2026-06-09T22:34:58Z | - |
| dc.date.issued | 2024 | pt_BR |
| dc.identifier.citation | BARBALHO, Geisa Nascimento; BRUGGER, Stefan; RAAB, Christian; LECHNER, Jara-Sophie; GRATIERI, Taís; KECK, Cornelia M.; RUPENTHAL, Ilva D.; AGARWAL, Priyanka. Development of transferosomes for topical ocular drug delivery of curcumin. European Journal of Pharmaceutics and Biopharmaceutics, [S. l.], v. 205, 114535, 2024. DOI: https://doi.org/10.1016/j.ejpb.2024.114535. Disponível em: https://www.sciencedirect.com/science/article/pii/S0939641124003618?via%3Dihub. Acesso em: 10 jun. 2026. | pt_BR |
| dc.identifier.uri | https://doi.org/10.1016/j.ejpb.2024.114535 | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/54680 | - |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier BV | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Development of transferosomes for topical ocular drug delivery of curcumin | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Medicamentos oftalmológicos - administração | - |
| dc.subject.keyword | Lipossomas | - |
| dc.subject.keyword | Transferossomos | - |
| dc.subject.keyword | Curcumina | - |
| dc.rights.license | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ). | - |
| dc.identifier.doi | https://doi.org/10.1016/j.ejpb.2024.114535 | pt_BR |
| dc.description.abstract1 | Background
Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have previously been used to enhance gradient driven penetration through the skin. This study aimed to evaluate the potential of TFS for topical ocular drug delivery and to compare their penetration enhancing properties in different ocular tissues.
Methods
Curcumin-loaded TFS were prepared using Tween 80 as the edge activator. Drug release and precorneal retention of the TFS were evaluated in vitro, while their ocular biocompatibility and bioavailability were evaluated ex vivo using a curcumin solution in medium chain triglycerides as the oily control.
Results
The TFS had a narrow size distribution with a particle size less than 150 nm and an entrapment efficiency greater than 99.96 %. Burst release from the TFS was minimal and the formulation showed good corneal biocompatibility. Moreover, enhanced corneal and conjunctival drug penetration with significantly greater and deeper drug delivery was observed with TFS.
Conclusion
TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues. | - |
| dc.identifier.orcid | https://orcid.org/0000-0001-6481-2364 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-8888-2340 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-5997-5994 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-3831-3833 | pt_BR |
| dc.contributor.affiliation | The University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics Unit | - |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) | - |
| dc.contributor.affiliation | The University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics Unit | - |
| dc.contributor.affiliation | Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics | - |
| dc.contributor.affiliation | Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics | - |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) | - |
| dc.contributor.affiliation | Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics | - |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) | - |
| dc.contributor.affiliation | University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) | - |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | - |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | - |
| dc.description.ppg | Programa de Pós-Graduação em Ciências Farmacêuticas | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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