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dc.contributor.authorMelo, Jéssica Luiza Mendonça Albuquerque de-
dc.contributor.authorNunes, Fernanda de Paula e Silva-
dc.contributor.authorCoelho, Camila Pinho e Souza-
dc.contributor.authorHeller, Debora-
dc.contributor.authorGuimarães, Maria do Carmo Machado-
dc.contributor.authorThuy Do-
dc.contributor.authorBorges, Luiz Gustavo dos Anjos-
dc.contributor.authorGrisi, Daniela Corrêa-
dc.contributor.authorTeixeira, Naile Dame-
dc.date.accessioned2026-05-14T13:48:20Z-
dc.date.available2026-05-14T13:48:20Z-
dc.date.issued2024-09-20-
dc.identifier.citationMELO, Jéssica Luiza Mendonça Albuquerque de et al. Low-level laser and transcutaneous electrical nerve stimulation on salivary glands impact type 2 diabetes mellitus oral microbiome: an interim analysis of a randomized trial. Lasers in Medical Science, [S. l.], v. 40, art. n. 372, 2025. DOI: https://doi.org/10.1007/s10103-025-04609-2.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54368-
dc.language.isoengpt_BR
dc.publisherSpringer Naturept_BR
dc.rightsAcesso Restritopt_BR
dc.titleLow-level laser and transcutaneous electrical nerve stimulation on salivary glands impact type 2 diabetes mellitus oral microbiome: an interim analysis of a randomized trialpt_BR
dc.typeArtigopt_BR
dc.subject.keywordDiabetespt_BR
dc.subject.keywordEstimulação elétricapt_BR
dc.subject.keywordEstimulação nervosa transncutâneapt_BR
dc.subject.keywordGlândulas salivarespt_BR
dc.subject.keywordMicrobioma oralpt_BR
dc.identifier.doihttps://doi.org/10.1007/s10103-025-04609-2pt_BR
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10103-025-04609-2pt_BR
dc.description.abstract1Purpose Diabetes Mellitus (DM) can lead to significant reduction of saliva production, which increases the risk of oral diseases. Managing reduced salivary flow becomes indispensable for restoring microbial balance in this condition. This study aimed to investigate the effects of physical stimulation methods on salivary secretion rate and microbiome composition in individuals with type 2 DM (T2DM) having reduced salivary flow using an exploratory interim analysis of a randomized clinical trial. Methods Eight individuals provided a total of 15 stimulated or rest saliva samples and were randomly assigned to the following groups: low-level laser therapy (LLLT) (G1), transcutaneous electrical nerve stimulation (TENS)(G2), and a combination of both methods(G3), administered twice a week over a span of 10 sessions. Salivary flow was evaluated at three time points: recruitment, before the 1st session (baseline) and after the 10th session. Subjective dry mouth was evaluated using the TESS scale at baseline and after the final session. DNA was extracted from whole saliva immediately before treatment (baseline) and after the final stimulation session, 16 S rRNA gene amplified and sequenced (Illumina MiSeq). Results N = 7 individuals showed improvement in stimulated salivary flow (SSF), achieving or maintaining normal range (SSF > 0.7 ml/min). Bacterial diversity was significantly higher in saliva after stimuli with laser(G1) when compared to TENS(G2). The relative abundance of Firmicutes and Fusobacteriota increased after all treatments, while Actinobacteriota and Proteobacteria decreased. The abundance of minority taxa was reduced after stimulation. Conclusion This exploratory study provides initial indications that physical stimulation may help manage T2DM-related reduced salivary flow and could be associated with subtle changes in low-abundance taxa suggesting a potential “clearance” effect. These preliminary observations require confirmation through larger, long-term studies.pt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUT Health San Antonio, San Antonio, USApt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversity of Leeds, Leeds, United Kingdompt_BR
dc.contributor.affiliationPontifical Catholic University of Rio Grande do Sulpt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Odontologia (FS ODT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Odontologiapt_BR
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