| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Assis, Alan Jhones Barbosa | - |
| dc.contributor.author | Santana, Brunna Letícia de Oliveira | - |
| dc.contributor.author | Gualberto, Ana Cristina Moura | - |
| dc.contributor.author | Silva, Fabio Pittella | - |
| dc.date.accessioned | 2026-05-12T13:19:27Z | - |
| dc.date.available | 2026-05-12T13:19:27Z | - |
| dc.date.issued | 2023-12 | - |
| dc.identifier.citation | ASSIS, Alan Jhones Barbosa et al. Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia: current perspectives, future challenges, and clinical implications. Frontiers in Pharmacology, [S. l.], v. 14, 1322937, 2023. DOI: https://doi.org/10.3389/fphar.2023.1322937. Disponível em: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1322937/full. Acesso em: 12 maio 2026. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/54351 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Frontiers | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia : current perspectives, future challenges, and clinical implications | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | CRISPR-Cas9 | pt_BR |
| dc.subject.keyword | Genética - estudo e ensino | pt_BR |
| dc.subject.keyword | Leucemia linfoblástica aguda (LLA) | pt_BR |
| dc.subject.keyword | Terapia celular | pt_BR |
| dc.subject.keyword | Câncer - tratamento | pt_BR |
| dc.rights.license | © 2023 Assis, Santana, Gualberto and Pittella-Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_BR |
| dc.identifier.doi | https://doi.org/10.3389/fphar.2023.1322937 | pt_BR |
| dc.description.abstract1 | Acute Lymphoblastic Leukemia (ALL) is the predominant hematological malignancy in pediatric populations, originating from B- or T-cell precursors within the bone marrow. The disease exhibits a high degree of heterogeneity, both at the molecular level and in terms of clinical presentation. A complex interplay between inherited and acquired genetic alterations contributes to disease pathogenesis, often resulting in the disruption of cellular functions integral to the leukemogenic process. The advent of CRISPR/Cas9 as a gene editing tool has revolutionized biological research, underscoring its potential to modify specific genomic loci implicated in cancer. Enhanced understanding of molecular alterations in ALL has facilitated significant advancements in therapeutic strategies. In this review, we scrutinize the application of CRISPR/Cas9 as a tool for identifying genetic targets to improve therapy, circumvent drug resistance, and facilitate CAR-T cell-based immunotherapy. Additionally, we discuss the challenges and future prospects of CRISPR/Cas9 applications in ALL. | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Sciences and Medicine, Laboratory of Molecular Pathology of Cancer | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Sciences and Medicine, Laboratory of Molecular Pathology of Cancer | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Sciences and Medicine, Laboratory of Molecular Pathology of Cancer | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Sciences and Medicine, Laboratory of Molecular Pathology of Cancer | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências Farmacêuticas | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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