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dc.contributor.authorGuimarães, Rayanne Poletti-
dc.contributor.authorResende, Maria Clara Souza de-
dc.contributor.authorTavares, Miguel Mesquita-
dc.contributor.authorAzevedo, Caio Belardinelli de-
dc.contributor.authorRuiz, Miguel Cesar Merino-
dc.contributor.authorMortari, Márcia Renata-
dc.date.accessioned2026-04-30T11:30:50Z-
dc.date.available2026-04-30T11:30:50Z-
dc.date.issued2024-08-
dc.identifier.citationGUIMARÃES, Rayanne Poletti. Construct, face, and predictive validity of Parkinson’s disease rodent models. International Journal of Molecular Sciences. v. 25, n. 16, 8971, 2024. DOI: https://doi.org/10.3390/ijms25168971. Disponível em: https://www.mdpi.com/1422-0067/25/16/8971. Acesso em: 29 abr. 2026.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/54324-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleConstruct, face, and predictive validity of Parkinson’s disease rodent modelspt_BR
dc.typeArtigopt_BR
dc.subject.keywordParkinson, Doença dept_BR
dc.subject.keywordModelos animaispt_BR
dc.subject.keywordValidade de construtopt_BR
dc.subject.keywordPesquisa translacionalpt_BR
dc.rights.license© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms25168971pt_BR
dc.description.abstract1Parkinson’s disease (PD) is the second most common neurodegenerative disease globally. Current drugs only alleviate symptoms without halting disease progression, making rodent models essential for researching new therapies and understanding the disease better. However, selecting the right model is challenging due to the numerous models and protocols available. Key factors in model selection include construct, face, and predictive validity. Construct validity ensures the model replicates pathological changes seen in human PD, focusing on dopaminergic neurodegeneration and a-synuclein aggregation. Face validity ensures the model’s symptoms mirror those in humans, primarily reproducing motor and non-motor symptoms. Predictive validity assesses if treatment responses in animals will reflect those in humans, typically involving classical pharmacotherapies and surgical procedures. This review highlights the primary characteristics of PD and how these characteristics are validated experimentally according to the three criteria. Additionally, it serves as a valuable tool for researchers in selecting the most appropriate animal model based on established validation criteria.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9253-2770pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0049-590Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7164-6704pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6849-6001pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Neuropharma Lab, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Neuropharma Lab, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Neuropharma Lab, Department of Physiological Sciencespt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Neuropharma Lab, Department of Physiological Sciencespt_BR
dc.contributor.affiliationSarah Network of Rehabilitation Hospitals, Neurological Rehabilitation Unitpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Neuropharma Lab, Department of Physiological Sciencespt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Patologia Molecularpt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animalpt_BR
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