| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Bedogni, Giselle R. | - |
| dc.contributor.author | Lima, Ana Luiza | - |
| dc.contributor.author | Gross, Idejan P. | - |
| dc.contributor.author | Menezes, Tatiana Prata | - |
| dc.contributor.author | Talvani, Andre | - |
| dc.contributor.author | Cunha-Filho, Marcílio | - |
| dc.contributor.author | Salomon, Claudio J. | - |
| dc.date.accessioned | 2026-02-23T19:29:08Z | - |
| dc.date.available | 2026-02-23T19:29:08Z | - |
| dc.date.issued | 2025-01 | - |
| dc.identifier.citation | Bedogni, G.R, et al. 3D-printed tablets of nifurtimox : in vitro and in vivo Anti-Trypanosoma cruzi studies. Pharmaceutics, [s. l.], v. 17, 2025. DOI: https://doi.org/10.3390/pharmaceutics17010080. Disponível em: https://www.mdpi.com/1999-4923/17/1/80. Acesso em: 23 fev. 2026. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/54090 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | 3D-printed tablets of nifurtimox : in vitro and in vivo Anti-Trypanosoma cruzi studies | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Impressão 3D | pt_BR |
| dc.subject.keyword | Nifurtimox | pt_BR |
| dc.subject.keyword | Modelagem 3D | pt_BR |
| dc.subject.keyword | Extrusão por fusão a quente | pt_BR |
| dc.subject.keyword | Moldagem de filmes | pt_BR |
| dc.subject.keyword | Atividade anti-T. cruzi | pt_BR |
| dc.rights.license | © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/pharmaceutics17010080 | pt_BR |
| dc.relation.publisherversion | https://www.mdpi.com/1999-4923/17/1/80 | pt_BR |
| dc.description.abstract1 | Chagas disease is a neglected tropical disease caused
by infection with the parasite Trypanosoma cruzi. Benznidazole and nifurtimox are the
only approved drugs for treating this condition, but their low aqueous solubility may
lead to erratic bioavailability. This work aimed for the first time to formulate tablets
of nifurtimox by hot melt extrusion coupled with 3D printing as a strategy to increase
drug dissolution and the production of tablets with dosage on demand. Methods: Different pharmaceutical-grade polymers were evaluated through film casting, and those with
promising nifurtimox amorphization capacity were further used to prepare filaments by hot
melt extrusion. The printability of the obtained filaments was tested, and the polyvinyl alcohol filament was further used for printing tablets containing 120 and 60 mg of nifurtimox.
Results: Three-dimensional tablets showed a remarkable improvement in the drug dissolution rate compared to commercial tablets and a dissolution efficiency 2.8 times higher.
In vivo studies were carried out on Swiss mice. Parasitemia curves of nifurtimox printed
tablets were significantly superior to the pure drug. Moreover, NFX 3D tablets provided a
similar Trypanosoma cruzi reduction in plasmatic concentration to benznidazole, the goldstandard drug for acute-phase treatment of the Chagas disease. Conclusions: The findings
of this work showed that hot melt extrusion coupled with 3D printing is a promising alternative for increasing nifurtimox biopharmaceutical properties and an attractive approach
for personalized medicine. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2177-8941 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-1798-7927 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4530-8987 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-6685-6229 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-9167-6852 | pt_BR |
| dc.contributor.affiliation | National Council for Scientific and Technical Research, Institute of Chemistry Rosario | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | Federal University of Ouro Preto | pt_BR |
| dc.contributor.affiliation | Federal University of Ouro Preto | pt_BR |
| dc.contributor.affiliation | University of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics | pt_BR |
| dc.contributor.affiliation | National Council for Scientific and Technical Research, National University of Rosario | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências da Saúde | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
