| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Barbosa, Cecília de Brito | - |
| dc.contributor.author | Silva, Isabela Monici | - |
| dc.contributor.author | Cena, Jéssica Alves de | - |
| dc.contributor.author | Stefani, Cristine Miron | - |
| dc.contributor.author | Teixeira, Nailê Damé | - |
| dc.date.accessioned | 2025-09-18T15:28:31Z | - |
| dc.date.available | 2025-09-18T15:28:31Z | - |
| dc.date.issued | 2023-10-31 | - |
| dc.identifier.citation | BARBOSA, Cecília de Brito et al. Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. Frontiers in Cellular and Infection Microbiology, v. 13, art. 1278754, 2023. DOI: DOI 10.3389/fcimb.2023.1278754. Disponível em: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1278754/full. Acesso em: 03 jul. 2025. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/52464 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Frontiers | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Presence of host and bacterial-derived collagenolytic proteases in carious dentin : a systematic review of ex vivo studies | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Dentes - dentina | pt_BR |
| dc.subject.keyword | Cárie dentária | pt_BR |
| dc.subject.keyword | Colagenase microbiana | pt_BR |
| dc.rights.license | © 2023 Barbosa, Monici Silva, Cena, Stefani and Dame-Teixeira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_BR |
| dc.identifier.doi | 10.3389/fcimb.2023.1278754 | pt_BR |
| dc.description.abstract1 | Introduction and aim: The presence of host collagenases in the degradation of
the protein matrix at later stages of carious dentin lesions development, as well as
the potential involvement of bacterial collagenases, have been suggested but
lack conclusive evidence. This study aims to conduct a systematic review to
comprehensively assess the profile of host and bacterial-derived collagenolytic
proteases in both root and coronal dentin carious lesions.
Methods: The search was performed in eight databases and the grey literature.
Studies evaluating ex vivo dentin, extracted teeth, or biofilms from natural caries
lesions were included. The methodological quality of studies was assessed using
the Joanna Briggs Institute tool. Synthesis of the results and the certainty of
evidence were performed following the Synthesis without Meta-analysis (SWiM)
checklist and GRADE approach for narrative synthesis, respectively.
Results: From 935 recovered articles, 18 were included. Although the evidence
was very uncertain, it was possible to suggest that 1) MMP-2, MMP-9, MMP-13,
and CT-B may be increased in carious dentin when compared to sound dentin; 2)
there is no difference in MMP-2 presence, while MMP-13 may be increased in
root when compared to coronal carious dentin; 3) there is no difference of MMP2 and MMP-9 expression/activity before and after cavity sealing; 4) MMP-8 may
be increased in the dentin before cavity sealing compared to dentin after cavity
sealing; 5) there is no difference of MMP-20 in irradiated vs. non-irradiated
carious dentin. MMP-20 probably reduces in carious outer dentin when
compared to carious inner dentin (moderate certainty). Genes encoding
bacterial collagenolytic proteases and protein-degrading bacteria were
detected in coronal and root carious lesions.
Conclusion: Trends in the direction of the effect were observed for some
collagenolytic proteases in carious dentin, which may represent a potential
target for the development of new treatments. (Protocol register-PROSPERO:
CRD42020213141). | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-1292-2371 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4010-4280 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-6442-5639 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-4712-9779 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-0490-0036 | pt_BR |
| dc.contributor.affiliation | University of Brasília, School of Health Sciences, Department of Dentistry | pt_BR |
| dc.contributor.affiliation | University of Brasília, School of Health Sciences, Department of Dentistry | pt_BR |
| dc.contributor.affiliation | University of Brasília, School of Health Sciences, Department of Dentistry | pt_BR |
| dc.contributor.affiliation | University of Brasília, School of Health Sciences, Department of Dentistry | pt_BR |
| dc.contributor.affiliation | University of Brasília, School of Health Sciences, Department of Dentistry | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Odontologia (FS ODT) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Odontologia | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
