Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/52462
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_LipidMetabolismModulation.pdf910,53 kBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorD’Avila, Heloisa-
dc.contributor.authorLima, Claudia Natércia Rocha-
dc.contributor.authorRampinelli, Pollianne Garbero-
dc.contributor.authorMateus, Laiza Camila Oliveira-
dc.contributor.authorSilva, Renata Vieira de Sousa-
dc.contributor.authorCorrêa, José Raimundo-
dc.contributor.authorAlmeida, Patrícia Elaine de-
dc.date.accessioned2025-09-18T14:49:34Z-
dc.date.available2025-09-18T14:49:34Z-
dc.date.issued2024-01-04-
dc.identifier.citationD’AVILA, Heloisa et al. Lipid metabolism modulation during SARS-CoV-2 infection: a spotlight on extracellular vesicles and therapeutic prospects. International Journal of Molecular Sciences, Basel, v. 25, n. 1, e640, 2024. DOI: https://doi.org/10.3390/ijms25010640. Disponível em: https://www.mdpi.com/1422-0067/25/1/640. Acesso em: 10 jul. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/52462-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleLipid metabolism modulation during SARS-CoV-2 infection : a spotlight on extracellular vesicles and therapeutic prospectspt_BR
dc.typeArtigopt_BR
dc.subject.keywordVesículas extracelularespt_BR
dc.subject.keywordMetabolismo lipídicopt_BR
dc.subject.keywordGotas lipídicaspt_BR
dc.subject.keywordInfecções por SARS-CoV-2pt_BR
dc.subject.keywordCovid-19pt_BR
dc.rights.license(CC BY) Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms25010640pt_BR
dc.description.abstract1Extracellular vesicles (EVs) have a significant impact on the pathophysiological processes associated with various diseases such as tumors, inflammation, and infection. They exhibit molecular, biochemical, and entry control characteristics similar to viral infections. Viruses, on the other hand, depend on host metabolic machineries to fulfill their biosynthetic requirements. Due to potential advantages such as biocompatibility, biodegradation, and efficient immune activation, EVs have emerged as potential therapeutic targets against the SARS-CoV-2 infection. Studies on COVID-19 patients have shown that they frequently have dysregulated lipid profiles, which are associated with an increased risk of severe repercussions. Lipid droplets (LDs) serve as organelles with significant roles in lipid metabolism and energy homeostasis as well as having a wide range of functions in infections. The down-modulation of lipids, such as sphingolipid ceramide and eicosanoids, or of the transcriptional factors involved in lipogenesis seem to inhibit the viral multiplication, suggesting their involvement in the virus replication and pathogenesis as well as highlighting their potential as targets for drug development. Hence, this review focuses on the role of modulation of lipid metabolism and EVs in the mechanism of immune system evasion during SARS-CoV-2 infection and explores the therapeutic potential of EVs as well as application for delivering therapeutic substances to mitigate viral infections.pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0005-7842-9389pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9785-8246pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2752-5395pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9081-8601pt_BR
dc.contributor.affiliationFederal University of Juiz de Fora, Department of Biology, Cell Biology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationFederal University of Juiz de Fora, Department of Biology, Cell Biology Laboratorypt_BR
dc.contributor.affiliationFederal University of Juiz de Fora, Department of Biology, Cell Biology Laboratorypt_BR
dc.contributor.affiliationFederal University of Juiz de Fora, Department of Biology, Cell Biology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationFederal University of Juiz de Fora, Department of Biology, Cell Biology Laboratorypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins
UnB - Covid-19

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.