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dc.contributor.authorLettieri, Giulia Melo-
dc.contributor.authorSantiago, Luander Medrado-
dc.contributor.authorLettieri, Giancarlo Crosara-
dc.contributor.authorBorges, Luiz Gustavo dos Anjos-
dc.contributor.authorMarconatto, Letícia-
dc.contributor.authorOliveira, Laudimar Alves de-
dc.contributor.authorTeixeira, Nailê Damé-
dc.contributor.authorSalles, Loise Pedrosa-
dc.date.accessioned2025-03-14T12:00:22Z-
dc.date.available2025-03-14T12:00:22Z-
dc.date.issued2021-08-26-
dc.identifier.citationLETTIERI, Giulia Melo et. al. Oral phenotype and salivary microbiome of individuals with Papillon–Lefèvre Syndrome. Frontiers in Cellular and Infection Microbiology, [S.l.], v. 11, 2021. DOI: https://doi.org/10.3389/fcimb.2021.720790. Disponível em: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.720790/full. Acesso em: 13 mar. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51886-
dc.language.isoengpt_BR
dc.publisherFrontierspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleOral phenotype and salivary microbiome of individuals with Papillon–Lefèvre Syndromept_BR
dc.typeArtigopt_BR
dc.subject.keywordPeriodontitept_BR
dc.subject.keywordMicrobiologiapt_BR
dc.subject.keywordDentes - doençaspt_BR
dc.subject.keywordCatepsina Cpt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.720790pt_BR
dc.description.abstract1Papillon–Lefèvre syndrome (PLS) is an autosomal recessive rare disease, main characteristics of which include palmoplantar hyperkeratosis and premature edentulism due to advanced periodontitis (formerly aggressive periodontitis). This study aimed to characterize the oral phenotype, including salivary parameters, and the salivary microbiome of three PLS sisters, comparatively. Two sisters were toothless (PLSTL1 and PLSTL2), and one sister had most of the teeth in the oral cavity (PLST). Total DNA was extracted from the unstimulated saliva, and the amplicon sequencing of the 16S rRNA gene fragment was performed in an Ion PGM platform. The amplicon sequence variants (ASVs) were obtained using the DADA2 pipeline, and the taxonomy was assigned using the SILVA v.138. The main phenotypic characteristics of PLS were bone loss and premature loss of primary and permanent dentition. The PLST sister presented advanced periodontitis with gingival bleeding and suppuration, corresponding to the advanced periodontitis as a manifestation of systemic disease, stage IV, grade C. All three PLS sisters presented hyposalivation as a possible secondary outcome of the syndrome. Interestingly, PLST salivary microbiota was dominated by the uncultured bacteria Bacterioidales (F0058), Fusobacterium, Treponema, and Sulfophobococcus (Archaea domain). Streptococcus, Haemophilus, and Caldivirga (Archaea) dominated the microbiome of the PLSTL1 sister, while the PLSTL2 had higher abundances of Lactobacillus and Porphyromonas. This study was the first to show a high abundance of organisms belonging to the Archaea domain comprising a core microbiome in human saliva. In conclusion, a PLST individual does have a microbiota different from that of the periodontitis’ aggressiveness previously recognized. Due to an ineffective cathepsin C, the impairment of neutrophils probably provided a favorable environment for the PLS microbiome. The interactions of Bacteroidales F0058, Caldivirga, and Sulfophobococcus with the microbial consortium of PLS deserves future investigation. Traditional periodontal therapy is not efficient in PLS patients. Unraveling the PLS microbiome is essential in searching for appropriate treatment and avoiding early tooth loss.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9369-8740pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0165-0681pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9300-1242pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8680-2375pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5578-5920pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7959-7150pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0490-0036pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1061-7963pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Dentistrypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Dentistrypt_BR
dc.contributor.affiliationSpecialized Center in Periodontology and Implantology, Periodontology Research Grouppt_BR
dc.contributor.affiliationHelmholtz Centre for Infection Research, Microbial Interactions and Processes Research Group, Braunschweig, Germanypt_BR
dc.contributor.affiliationPontifical Catholic University of Rio Grande do Sul, Institute of Petroleum and Natural Resourcespt_BR
dc.contributor.affiliationHelmholtz Centre for Infection Research, Microbial Interactions and Processes Research Group, Braunschweig, Germanypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Dentistrypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Dentistrypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Dentistrypt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Odontologia (FS ODT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Odontologiapt_BR
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