Titre:	Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA
Auteur(s):	Teixeira, Tamara Ribeiro, Gabriel H. Gonçalves, Guilherme R. Araújo Neto, João Honorato de Oliveira, Katia Mara de Correa, Rodrigo S.
metadata.dc.contributor.email:	mailto:tamarateixeira@estudante.ufscar.br
metadata.dc.identifier.orcid:	https://orcid.org/0000-0002-1127-6083 https://orcid.org/0000-0003-4749-0281
metadata.dc.contributor.affiliation:	Chemistry Department, ICEB, Federal University of Ouro Preto – UFOP Embrapa Chemistry Department, ICEB, Federal University of Ouro Preto – UFOP Physics Institute of São Carlos, University of São Paulo – USP Universidade de Brasília https://orcid.org/0000-0003-2783-0816
Assunto::	Rutênio Elementos químicos - atividade citotóxica Mamas - câncer - tratamento
Date de publication:	22-avr-2024
Editeur:	Elsevier
Référence bibliographique:	TEIXEIRA, Tamara et. al. Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA. Inorganica Chimica Acta, v. 568, art. 122078, 1 ago. 2024. DOI 10.1016/j.ica.2024.122078. Disponível em: https://www.sciencedirect.com/science/article/pii/S0020169324001683?via%3Dihub. Acesso em: 13 mar. 2025.
Abstract:	New ruthenium(II) complexes bearing benzoate (AB) ligand with the general formula [Ru(AB)(bipy)(P–P)]PF6, where 2,2′-bipyridine (bipy) and different diphosphine ligands, (P–P) = 1,2′-bis(diphenylphosphine)ethane(dppe, 1), 1,3′-bis(diphenylphosphine)propane (dppp, 2) and 1,2′-bis(diphenylphosphine)ferrocene (dppf, 3), were synthesized. The compounds were characterized by molar conductivity, elemental analysis, cyclic voltammetry, infrared and UV–Vis spectroscopies, NMR, and by single-crystal X-ray diffraction for complexes 1 and 2. The complexes showed a weak interaction to CT-DNA through DNA minor groove, with Kb values at around 103-104 M− 1. CT-DNA interaction assays by viscosity and circular dichroism (CD) suggested that the compounds do not significantly alter the secondary DNA structure. The complexes are cytotoxic against MDA-MB-231, MCF7 (breast) and A549 (lung) tumor cell lines, with IC50 values in the range of 1 to 17 µM. The compounds 1-3 showed high selectivity against triple-negative breast tumor cells. Remarkably, complexes 1 and 3 show greater cytotoxic activity against cells than cisplatin, being promising agents for tumor treatment.
metadata.dc.description.unidade:	Instituto de Química
Licença::	© 2024 Elsevier B.V. All rights reserved.
DOI:	https://doi.org/10.1016/j.ica.2024.122078
metadata.dc.relation.publisherversion:	https://www.sciencedirect.com/science/article/pii/S0020169324001683?via%3Dihub
Collection(s) :	Artigos publicados em periódicos e afins

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